CD44, IL-33, and ST2 Gene Polymorphisms on Hepatocellular Carcinoma Susceptibility in the Chinese Population
Joint Authors
Pan, Xiaolan
Huang, Lei
Li, Meiqin
Mo, Dan
Liang, Yihua
Huang, Zhaodong
Zhu, Bo
Fang, Min
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-09-29
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The interleukin- (IL-) 33/ST2 axis plays a pivotal role in tumorigenesis through influencing cancer stemness and other mechanisms.
CD44 is one of the critical markers of hepatocellular carcinoma (HCC) among the cancer stem cells (CSCs).
There is still a lack of CD44 gene single-nucleotide polymorphisms (SNPs) combined with IL-33/ST2 pathway single-nucleotide polymorphisms in HCC susceptibility analysis literature, although CD44 and IL-33/ST2 have been reported separately in human cancers.
This study is aimed at investigating the relationship between CD44, IL-33, and ST2 SNPs and HCC susceptibility and clinicopathological features.
We analyzed 565 HCC patients and 561 healthy controls in the Chinese population.
The genes for CD44rs187115A>G, IL-33 rs1929992A>G, and ST2 rs3821204G>C were typed using the SNaPshot method.
We found that the distribution frequencies of CD44 and ST2 alleles and genotypes in both the HCC case group and the control group were statistically significant (p<0.05).
The results showed that individuals carrying at least one G allele of the CD44 rs187115 gene were at a higher risk than the AA genotype carriers (p=0.007, odds ratio OR=1.429, 95% confidence interval (CI): 1.102–1.854).
Similarly, individuals with at least one C allele of ST2 rs3821204 had a higher risk of HCC than those with GG genes (p≤0.001, OR=1.647, 95% CI: 1.296-2.093).
Combining the haplotype analysis of the 3 loci suggested that CD44 rs187115, IL-33 rs1929992, and ST2 rs3821204 are associated with the risk of HCC and could potentially serve as useful genetic markers for HCC in some populations of China.
American Psychological Association (APA)
Pan, Xiaolan& Li, Meiqin& Huang, Lei& Mo, Dan& Liang, Yihua& Huang, Zhaodong…[et al.]. 2020. CD44, IL-33, and ST2 Gene Polymorphisms on Hepatocellular Carcinoma Susceptibility in the Chinese Population. BioMed Research International،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1132809
Modern Language Association (MLA)
Pan, Xiaolan…[et al.]. CD44, IL-33, and ST2 Gene Polymorphisms on Hepatocellular Carcinoma Susceptibility in the Chinese Population. BioMed Research International No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1132809
American Medical Association (AMA)
Pan, Xiaolan& Li, Meiqin& Huang, Lei& Mo, Dan& Liang, Yihua& Huang, Zhaodong…[et al.]. CD44, IL-33, and ST2 Gene Polymorphisms on Hepatocellular Carcinoma Susceptibility in the Chinese Population. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1132809
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1132809