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The Role of Marine Organic Extract in Bone Regeneration: A Pilot Study
Joint Authors
Vendramini, Ivana
Corso, Paola Fernanda Cotait de Lucas
Muller, Leonardo Luiz
Crivellaro, Viviane Rozeira
Khajotia, Sharukh Soli
Esteban Florez, Fernando Luis
Scariot, Rafaela
Elsalanty, Mohammed
Storrer, Carmen Lucia Mueller
Deliberador, Tatiana Miranda
Zielak, João César
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-02-18
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Novel biomaterials capable of accelerating the healing process of skeletal tissues are urgently needed in dentistry.
The present in vivo study assessed the osteoconductive and osteoinductive properties of experimental biphasic bioceramics (HA-TCP) modified or not by a nacre extract (marine organic extract, MOE) in a sheep model.
Fabrication of MOE involved mixing ground nacre (0.05 g, particle sizes < 0.1 mm) with glacial ethanoic acid (5 mL, pH 7) for 72 hours using external magnetic stirring (25°C).
Nonreactive carriers (sterile polythene tubes; 3/animal, radius: 2.5 mm, length: 10.0 mm) pertaining to the control (empty) or experimental groups (HA-TCP or MOE-modified HA-TCP) were implanted intramuscularly into the abdominal segment of the torso in sheep (n = 8, age: 2 years, weight: 45 kg).
Euthanization of animals was performed at 3 and 6 months after surgery.
Tissues harvested were subjected to macroscopic and radiographic assessments.
Specimens were then stained for histological analysis.
Both control and experimental animals were capable of inducing the neoformation of fibrous connective tissue at both time points where superior amounts of tissue formation and mineralization were detected for experimental groups (unaltered (at 3 and 6 mos) and MOE-modified HA-TCP (at 3 mos)).
Histological results, however, revealed that mature bone formation was only observed for specimens fabricated with MOE-modified HA-TCP in a time-dependent manner.
The present study has successfully demonstrated the in vivo utility of experimental biphasic bioceramics modified by MOE in an ectopic grafting sheep model.
Promising osteoconductive and osteoinductive properties must be further developed and confirmed by subsequent research.
American Psychological Association (APA)
Zielak, João César& Vendramini, Ivana& Corso, Paola Fernanda Cotait de Lucas& Muller, Leonardo Luiz& Crivellaro, Viviane Rozeira& Khajotia, Sharukh Soli…[et al.]. 2020. The Role of Marine Organic Extract in Bone Regeneration: A Pilot Study. BioMed Research International،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1132816
Modern Language Association (MLA)
Zielak, João César…[et al.]. The Role of Marine Organic Extract in Bone Regeneration: A Pilot Study. BioMed Research International No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1132816
American Medical Association (AMA)
Zielak, João César& Vendramini, Ivana& Corso, Paola Fernanda Cotait de Lucas& Muller, Leonardo Luiz& Crivellaro, Viviane Rozeira& Khajotia, Sharukh Soli…[et al.]. The Role of Marine Organic Extract in Bone Regeneration: A Pilot Study. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1132816
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1132816