Association between Triglyceride-Glucose Index and Type 2 Diabetes Mellitus in the Japanese Population: A Secondary Analysis of a Retrospective Cohort Study
Joint Authors
Liu, En-qian
Weng, Ya-ping
Zhou, Ai-ming
Zeng, Chun-lai
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-12-11
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Triglyceride-glucose index (TyG index) is associated with type 2 diabetes mellitus (T2DM), but research on this relationship is limited in Japan.
The purpose of this study was to evaluate the correlation between TyG index and the risk of T2DM in the Japanese population.
Here, 12732 participants were selected from the NAGALA study (NAfld in the Gifu Area, Longitudinal Analysis) conducted between 2004 and 2015 for a retrospective cohort analysis.
The association between TyG index and T2DM was assessed using the Cox proportional-hazard model.
Subgroup analyses were conducted according to age, sex, smoking status, alcohol consumption, waist circumference, BMI, and follow-up duration.
The formula for TyG index was expressed as ln fasting triglyceride level mg/dL×fasting plasma glucose level mg/dL/2.
After follow-up, 150 (1.18%) patients developed T2DM.
After adjusting for potential confounders, a linear relationship was observed between TyG and the risk of T2DM.
After adjusting for age, sex, BMI, waist circumference, HDL-cholesterol, total cholesterol, systolic blood pressure, regular exercise, smoking status, and alcohol consumption, TyG index, as a continuous variable, was associated with an increased risk of T2DM (adjusted hazard ratio (aHR), 1.79; 95% confidence interval (95% CI), 1.25-2.57).
Compared with the first quartile of TyG index, subjects in the fourth quartile were 2.33-fold more likely to develop T2DM (aHR 2.33, 95% CI 1.09-4.96; P for trend 0.0224).
Subgroup analyses showed that the association between TyG index and incident T2DM stably existed in different subgroups according to the variables tested.
Therefore, TyG index was linearly related to the risk of incident T2DM in the Japanese population and may be used as a monitoring tool.
American Psychological Association (APA)
Liu, En-qian& Weng, Ya-ping& Zhou, Ai-ming& Zeng, Chun-lai. 2020. Association between Triglyceride-Glucose Index and Type 2 Diabetes Mellitus in the Japanese Population: A Secondary Analysis of a Retrospective Cohort Study. BioMed Research International،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1132846
Modern Language Association (MLA)
Liu, En-qian…[et al.]. Association between Triglyceride-Glucose Index and Type 2 Diabetes Mellitus in the Japanese Population: A Secondary Analysis of a Retrospective Cohort Study. BioMed Research International No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1132846
American Medical Association (AMA)
Liu, En-qian& Weng, Ya-ping& Zhou, Ai-ming& Zeng, Chun-lai. Association between Triglyceride-Glucose Index and Type 2 Diabetes Mellitus in the Japanese Population: A Secondary Analysis of a Retrospective Cohort Study. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1132846
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1132846