Liraglutide Attenuates Nonalcoholic Fatty Liver Disease by Modulating Gut Microbiota in Rats Administered a High-Fat Diet
Joint Authors
Bi, Yan
Zhu, Dalong
Zhang, Ningjing
Tao, Junxian
Gao, Lijun
Li, Ping
Wang, Hongdong
Feng, Wenhuan
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-02-18
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
This study aimed to determine whether modulation of the gut microbiota structure by liraglutide helps improve nonalcoholic fatty liver disease (NAFLD) in rats on a high-fat diet (HFD).
Rats were administered an HFD for 12 weeks to induce NAFLD and then administered liraglutide for 4 additional weeks.
Next-generation sequencing and multivariate analysis were performed to assess structural changes in the gut microbiota.
Liraglutide attenuated excessive hepatic ectopic fat deposition, maintained intestinal barrier integrity, and alleviated metabolic endotoxemia in HFD rats.
Liraglutide significantly altered the overall structure of the HFD-disrupted gut microbiota and gut microbial composition in HFD rats in comparison to those on a normal diet.
An abundance of 100 operational taxonomic units (OTUs) were altered upon liraglutide administration, with 78 OTUs associated with weight gain or inflammation.
Twenty-three OTUs positively correlated with hepatic steatosis-related parameters were decreased upon liraglutide intervention, while 5 OTUs negatively correlated with hepatic steatosis-related parameters were increased.
These results suggest that liraglutide-mediated attenuation of NAFLD partly results from structural changes in gut microbiota associated with hepatic steatosis.
American Psychological Association (APA)
Zhang, Ningjing& Tao, Junxian& Gao, Lijun& Bi, Yan& Li, Ping& Wang, Hongdong…[et al.]. 2020. Liraglutide Attenuates Nonalcoholic Fatty Liver Disease by Modulating Gut Microbiota in Rats Administered a High-Fat Diet. BioMed Research International،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1132849
Modern Language Association (MLA)
Zhang, Ningjing…[et al.]. Liraglutide Attenuates Nonalcoholic Fatty Liver Disease by Modulating Gut Microbiota in Rats Administered a High-Fat Diet. BioMed Research International No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1132849
American Medical Association (AMA)
Zhang, Ningjing& Tao, Junxian& Gao, Lijun& Bi, Yan& Li, Ping& Wang, Hongdong…[et al.]. Liraglutide Attenuates Nonalcoholic Fatty Liver Disease by Modulating Gut Microbiota in Rats Administered a High-Fat Diet. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1132849
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1132849