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Association between MMPTIMP Levels in the Aqueous Humor and Plasma with Axial Lengths in Myopia Patients
Joint Authors
Yue, Yu
Hsiao, Yu-Wen
Zhou, Jibo
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-06-11
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Purpose.
The present study investigated the profiles of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) of the aqueous humor (AH) and plasma (PL) in myopia patients, to determine whether there was an association between these levels with their axial length (AL) and to investigate if MMPs/TIMPs were regulated locally or systemically.
Methods.
A cross-sectional study was conducted.
Thirty-nine patients (78 eyes) diagnosed with high myopia were recruited.
The AL was measured using IOL Master.
And the patients were divided into three groups based on their AL, Group A (AL≤26 mm), Group B (26
The AH in both eyes and blood samples were collected before the patients underwent implantable collamer lens surgery.
In all, 78 samples of the AH and 39 samples of the PL were analyzed using MILLIPLEX map assays, followed by statistical analyses of the results.
Results.
There were 8 patients (16 eyes) in Group A, 22 patients (44 eyes) in Group B, and 9 patients (18 eyes) in Group C.
MMP-1 (p=0.014, Β=0.118), MMP-2 (p≤0.001, Β=0.278), MMP-9 (p≤0.001, Β=0.019), and TIMP-1 (p=0.014, Β=0.062) in the AH were positively associated with the AL.
MMP-1 (p=0.004, Β=0.001) and TIMP-1 (p=0.030, Β=1.171) concentrations in the PL increased linearly with longer ALs.
No concentration-dependent relationship was found between MMP-2 in the PL and AL.
Conclusions.
There was a consistent relationship between MMP-2 in the AH and AL.
AL was not consistently or substantially affected by MMP-2 in the PL, indicating myopia formation was possibly a localized process.
Associations among MMP-1, MMP-9, and TIMP-1 in the AH and AL were also observed.
American Psychological Association (APA)
Yue, Yu& Hsiao, Yu-Wen& Zhou, Jibo. 2020. Association between MMPTIMP Levels in the Aqueous Humor and Plasma with Axial Lengths in Myopia Patients. BioMed Research International،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1132870
Modern Language Association (MLA)
Yue, Yu…[et al.]. Association between MMPTIMP Levels in the Aqueous Humor and Plasma with Axial Lengths in Myopia Patients. BioMed Research International No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1132870
American Medical Association (AMA)
Yue, Yu& Hsiao, Yu-Wen& Zhou, Jibo. Association between MMPTIMP Levels in the Aqueous Humor and Plasma with Axial Lengths in Myopia Patients. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1132870
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1132870