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Hypouricemic Effects of Extracts from Urtica hyperborea Jacq. ex Wedd. in Hyperuricemia Mice through XOD, URAT1, and OAT1
Joint Authors
Luo, Weizao
Han, Surina
Wei, Rongrui
Han, Daorina
Zhu, Jixiao
Ao, Wuliji
Zhong, Guoyue
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-01-30
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Urtica L.
has been long used for gout in traditional Tibetan medicine and is closely related to the effect of reducing uric acid.
This study aimed to investigate the effect of Urtica hyperborea Jacq.
ex Wedd.
(UW) on lowering uric acid and its mechanism by using HK2 cells and hyperuricemia mouse model.
Petroleum ether extract (UWP), ethyl acetate extract (UWE), n-butanol extract (UWB), and alcohol-soluble extract (UWA) from UW were prepared, and HK2 cells were treated with various parts extracts to observe the expression of uric acid transporter at 25, 50, and 100 μg/mL for 24 h.
Moreover, hyperuricemia mice were administered orally various parts extracts at 0.78 and 2.34 g/kg (crude drug dose converted by extraction rate) to observe the change of hepatic XOD, serum ADA, renal function, and uric acid transporter.
In vitro experiments showed that UWA can remarkably elevate OAT1 expression and decrease URAT1 expression in HK2 cells.
In vivo experiments showed that UWP, UWE, UWB, and UWA showed remarkable activity in reducing uric acid, rendering a substantial decline in the SUA level in hyperuricemia mice.
Compared with the hyperuricemia and allopurinol groups, UWB and UWA had significant protective effects on renal injury.
At the same time, UWA can significantly reduce the activity of XOD and ADA, reduce the expression of URAT1, and increase the expression of OAT1.
These results indicated that UWA had an outstanding uric acid lowering effect and did not affect renal function.
This may be related to increased uric acid excretion and decreased uric acid production, mediated by renal OAT1, URAT1, liver XOD, and serum ADA.
UWA may be a potential drug against hyperuricemia.
American Psychological Association (APA)
Han, Surina& Wei, Rongrui& Han, Daorina& Zhu, Jixiao& Luo, Weizao& Ao, Wuliji…[et al.]. 2020. Hypouricemic Effects of Extracts from Urtica hyperborea Jacq. ex Wedd. in Hyperuricemia Mice through XOD, URAT1, and OAT1. BioMed Research International،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1132873
Modern Language Association (MLA)
Han, Surina…[et al.]. Hypouricemic Effects of Extracts from Urtica hyperborea Jacq. ex Wedd. in Hyperuricemia Mice through XOD, URAT1, and OAT1. BioMed Research International No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1132873
American Medical Association (AMA)
Han, Surina& Wei, Rongrui& Han, Daorina& Zhu, Jixiao& Luo, Weizao& Ao, Wuliji…[et al.]. Hypouricemic Effects of Extracts from Urtica hyperborea Jacq. ex Wedd. in Hyperuricemia Mice through XOD, URAT1, and OAT1. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1132873
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1132873