Mesenteric Lymph Duct Drainage Attenuates Lung Inflammatory Injury and Inhibits Endothelial Cell Apoptosis in Septic Rats
Joint Authors
Ma, Jie
Liu, Yongjun
Chen, Chuanxi
Sun, Huadong
Liu, Ning
Liu, Qier
Wang, Pingping
Hu, Chunlin
Wu, Jianfeng
Ouyang, Bin
Chen, Juan
Chen, Minying
Guan, Xiangdong
Sun, Qing
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-10-21
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The present study was to investigate the effect of mesenteric lymph duct drainage on lung inflammatory response, histological alteration, and endothelial cell apoptosis in septic rats.
Animals were randomly assigned into four groups: control, sham surgery, sepsis, and sepsis plus mesenteric lymph drainage.
We used the colon ascendens stent peritonitis (CASP) procedure to induce the septic model in rats, and mesenteric lymph drainage was performed with a polyethylene (PE) catheter inserted into mesenteric lymphatic.
The animals were sacrificed at the end of CASP in 6 h.
The mRNA expression levels of inflammatory mediators were measured by qPCR, and the histologic damage were evaluated by the pathological score method.
It was found that mesenteric lymph drainage significantly reduced the expression of TNF-α, IL-1β, and IL-6 mRNA in the lung.
Pulmonary interstitial edema and infiltration of inflammatory cells were alleviated by mesenteric lymph drainage.
Moreover, increased mRNA levels of TNF-α, IL-1β, IL-6 mRNA, and apoptotic rate were observed in PMVECs treated with septic lymph.
These results indicate that mesenteric lymph duct drainage significantly attenuated lung inflammatory injury by decreasing the expression of pivotal inflammatory mediators and inhibiting endothelial apoptosis to preserve the pulmonary barrier function in septic rats.
American Psychological Association (APA)
Liu, Yongjun& Chen, Chuanxi& Sun, Qing& Sun, Huadong& Liu, Ning& Liu, Qier…[et al.]. 2020. Mesenteric Lymph Duct Drainage Attenuates Lung Inflammatory Injury and Inhibits Endothelial Cell Apoptosis in Septic Rats. BioMed Research International،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1132933
Modern Language Association (MLA)
Liu, Yongjun…[et al.]. Mesenteric Lymph Duct Drainage Attenuates Lung Inflammatory Injury and Inhibits Endothelial Cell Apoptosis in Septic Rats. BioMed Research International No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1132933
American Medical Association (AMA)
Liu, Yongjun& Chen, Chuanxi& Sun, Qing& Sun, Huadong& Liu, Ning& Liu, Qier…[et al.]. Mesenteric Lymph Duct Drainage Attenuates Lung Inflammatory Injury and Inhibits Endothelial Cell Apoptosis in Septic Rats. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1132933
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1132933