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Combined Pharmacotherapy with Alendronate and Desferoxamine Regulate the Bone Resorption and Bone Regeneration for Preventing Glucocorticoids-Induced Osteonecrosis of the Femoral Head
Joint Authors
Sheng, Hongfeng
Lao, Yangjun
Zhang, Shuliang
Ding, Weiguo
Xu, Bin
Lu, Di
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-09-24
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Background.
Osteonecrosis of the femoral head (ONFH) is a challenge for surgeons and is still without effective treatment method.
This study is aimed at evaluating the combined pharmacotherapy with alendronate and desferoxamine for preventing glucocorticoid-induced osteonecrosis of the femoral head (GIOFH) and evaluating the efficacy of the combined medicine in regulating the bone resorption and bone regeneration.
Materials and Methods.
Thirty-six rats were randomly assigned to three groups: group A received alendronate and desferoxamine (n=12), group B received alendronate only (n=12), and group C acted as the control group received placebo (n=12).
All rats induced the GIOFH using methylprednisolone combined with lipopolysaccharide.
Eight weeks later, all rats were killed and their tissues were subjected to radiographic and histological analyses.
Results.
According to the results, alendronate administration improved the trabecular thickness and separation in micro-CT analysis but had no significant evidence in increasing the bone area and decreasing the ratio of osteocyte lacunae in histological analysis when compared with the control group.
Meanwhile, the alendronate group had more OCs, but less OCN and VEGF levels along with decreased p-AKT, HIF-1α, RANKL, and NFATc1 expressions than the control group.
For comparison, alendronate combined with DFO further improved the bone volume, trabecular number, trabecular separation, and trabecular thickness with lower ratio of osteocyte lacunae and OC number, higher expression of OCN and VEGF and upregulated signal factors of HIF-1α and β-catenin, and decreased RANKL and NFATc1.
Conclusion.
Combined pharmacotherapy with alendronate and desferoxamine provide significant effects in regulating the bone resorption and bone regeneration for preventing GIOFN.
American Psychological Association (APA)
Sheng, Hongfeng& Lao, Yangjun& Zhang, Shuliang& Ding, Weiguo& Lu, Di& Xu, Bin. 2020. Combined Pharmacotherapy with Alendronate and Desferoxamine Regulate the Bone Resorption and Bone Regeneration for Preventing Glucocorticoids-Induced Osteonecrosis of the Femoral Head. BioMed Research International،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1133007
Modern Language Association (MLA)
Sheng, Hongfeng…[et al.]. Combined Pharmacotherapy with Alendronate and Desferoxamine Regulate the Bone Resorption and Bone Regeneration for Preventing Glucocorticoids-Induced Osteonecrosis of the Femoral Head. BioMed Research International No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1133007
American Medical Association (AMA)
Sheng, Hongfeng& Lao, Yangjun& Zhang, Shuliang& Ding, Weiguo& Lu, Di& Xu, Bin. Combined Pharmacotherapy with Alendronate and Desferoxamine Regulate the Bone Resorption and Bone Regeneration for Preventing Glucocorticoids-Induced Osteonecrosis of the Femoral Head. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1133007
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1133007