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Prevalence and Risk Factors of Cytopenia in HIV-Infected Patients before and after the Initiation of HAART
Joint Authors
Zhao, Hongxin
Fan, Lina
Li, Cuilin
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-01-29
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background.
Cytopenia is a frequent hematological disorder in patients with human immunodeficiency virus (HIV) infection.
However, the distribution and risk factors of cytopenia in patients starting highly active anti-retrovirus treatment (HAART) and the effect of HAART on cytopenia were not fully investigated.
Methods.
From November 2004 to August 2016, a retrospective study was conducted to evaluate the prevalence of cytopenia in 4325 HAART-naïve patients.
Risk factors of cytopenia at baseline and on recovery from cytopenia were analyzed using logistic regression analysis after 24 months of HAART in Beijing Ditan Hospital.
Results.
The prevalence of cytopenia was 19.1% in HIV-naïve patients.
Risk factors for cytopenia in HAART-naïve patients were a CD4 cell count<200 cells/μL, femaleness, WHO stage IV, coinfection with hepatitis B virus (HBV), BMI <18.5 kg/m2, a viral load ≥100,000 copies/ml, and age ≥40 years.
In total, 70.2% and 76.4% of patients with cytopenia recovered after 6 and 24 months of HAART, respectively.
The predictors of patients without normal blood cells after 24 months HAART were a CD4 cell count of <200 cells/μL at baseline, femaleness, WHO stage IV, coinfection with HBV, and treatment with AZT.
Conclusion.
Early detection could decrease the prevalence of HIV-related cytopenia, while starting HAART as early as possible seems to be effective for normalization of the blood cells in HIV-infected patients.
American Psychological Association (APA)
Fan, Lina& Li, Cuilin& Zhao, Hongxin. 2020. Prevalence and Risk Factors of Cytopenia in HIV-Infected Patients before and after the Initiation of HAART. BioMed Research International،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1133017
Modern Language Association (MLA)
Fan, Lina…[et al.]. Prevalence and Risk Factors of Cytopenia in HIV-Infected Patients before and after the Initiation of HAART. BioMed Research International No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1133017
American Medical Association (AMA)
Fan, Lina& Li, Cuilin& Zhao, Hongxin. Prevalence and Risk Factors of Cytopenia in HIV-Infected Patients before and after the Initiation of HAART. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1133017
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1133017