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Reference Values of D-Dimers and Fibrinogen in the Course of Physiological Pregnancy: the Potential Impact of Selected Risk Factors—A Pilot Study
Joint Authors
Torbé, Andrzej
Siennicka, Aldona
Jastrzębska, Maria
Kłysz, Magdalena
Chełstowski, Kornel
Tabaczniuk, Aleksandra
Marcinowska, Zuzanna
Tarnowska, Paulina
Kulesza, Jolanta
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-05-27
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Pregnancy predisposes to thrombotic hemostasis, reflected in the laboratory as, e.g., increased levels of D-Dimers and fibrinogen, but in physiological pregnancy, the risk of venous thrombosis does not increase.
Risk may increase if gestational diabetes mellitus (GDM) or nicotinism coexists.
Study aims were to determine reference values for D-Dimers and fibrinogen concentrations in each trimester of pregnancy, corrected for GDM and nicotinism.
Subjects and Methods.
The study involved 71 pregnant women aged 25-44 y.
Venous blood was collected three times: in the first (11-14 weeks), second (20-22 weeks), and third (30-31 weeks) trimesters.
D-Dimer concentrations were determined by an enzyme-linked fluorescence assay, fibrinogen concentrations by a coagulation method according to Clauss.
Results.
Significant increases in D-Dimers and fibrinogen concentrations were observed, increasing with successive trimesters (p ANOVA<0.0001).
Furthermore, a positive correlation between D-Dimers and fibrinogen was detected in the second trimester of pregnancy (r=0.475; p<0.0001).
In addition, a significantly higher fibrinogen concentration was found in women with GDM compared to without GDM (p=0.0449).
Reference ranges for D-Dimers were established, in trimester order, as follows: 167-721 ng/mL, 298-1653 ng/mL, and 483-2256 ng/mL.
After adjusting for risk factors, significantly higher D-Dimer values (mainly second and third trimesters) were obtained: 165-638 ng/mL, 282-3474 ng/mL, and 483-4486 ng/mL, respectively.
Reference ranges for fibrinogen were, in trimester order, 2.60-6.56 g/L, 3.40-8.53 g/L, and 3.63-9.14 g/L and, after adjustment for risk factors, 3.34-6.73 g/L, 3.40-8.84 g/L, and 3.12-9.91 g/L.
Conclusions.
We conclude that the increase in D-Dimers and fibrinogen levels in women with physiological pregnancy was compounded by gestational diabetes (GDM) and nicotinism.
Therefore, D-Dimers and fibrinogen pregnancy reference values require correction for these risk factors.
American Psychological Association (APA)
Siennicka, Aldona& Kłysz, Magdalena& Chełstowski, Kornel& Tabaczniuk, Aleksandra& Marcinowska, Zuzanna& Tarnowska, Paulina…[et al.]. 2020. Reference Values of D-Dimers and Fibrinogen in the Course of Physiological Pregnancy: the Potential Impact of Selected Risk Factors—A Pilot Study. BioMed Research International،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1133061
Modern Language Association (MLA)
Siennicka, Aldona…[et al.]. Reference Values of D-Dimers and Fibrinogen in the Course of Physiological Pregnancy: the Potential Impact of Selected Risk Factors—A Pilot Study. BioMed Research International No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1133061
American Medical Association (AMA)
Siennicka, Aldona& Kłysz, Magdalena& Chełstowski, Kornel& Tabaczniuk, Aleksandra& Marcinowska, Zuzanna& Tarnowska, Paulina…[et al.]. Reference Values of D-Dimers and Fibrinogen in the Course of Physiological Pregnancy: the Potential Impact of Selected Risk Factors—A Pilot Study. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1133061
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1133061