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Silencing ARAF Suppresses the Malignant Phenotypes of Gallbladder Cancer Cells
Joint Authors
Lin, Weiguo
Tong, Chenhao
Zhang, Weiguang
Cen, Wenda
Wang, Yali
Li, Jiandong
Zhu, Zhiyang
Yu, Jianhua
Lu, Baochun
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-08-19
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
ARAF is a member of the RAF kinase family that is necessary for mitogen-activated protein kinase (MAPK) activation in various malignancies, including lung, colorectal, pancreatic, and breast cancers.
As the most common biliary tract tumor, gallbladder cancer (GBC) seriously harms human health while the function of ARAF in GBC remains elusive.
Here, we found that ARAF expression was upregulated in gallbladder cancer tissues.
In vitro, ARAF silencing mediated by RNA interference effectively inhibited cell proliferation, colony formation, migration, and invasion of GBC cells.
Moreover, knocking down ARAF suppressed tumor growth in vivo.
Our results indicated that ARAF functions as an oncogene in GBC and, thus, could be a potential therapeutic target for GBC.
American Psychological Association (APA)
Lin, Weiguo& Tong, Chenhao& Zhang, Weiguang& Cen, Wenda& Wang, Yali& Li, Jiandong…[et al.]. 2020. Silencing ARAF Suppresses the Malignant Phenotypes of Gallbladder Cancer Cells. BioMed Research International،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1133085
Modern Language Association (MLA)
Lin, Weiguo…[et al.]. Silencing ARAF Suppresses the Malignant Phenotypes of Gallbladder Cancer Cells. BioMed Research International No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1133085
American Medical Association (AMA)
Lin, Weiguo& Tong, Chenhao& Zhang, Weiguang& Cen, Wenda& Wang, Yali& Li, Jiandong…[et al.]. Silencing ARAF Suppresses the Malignant Phenotypes of Gallbladder Cancer Cells. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1133085
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1133085