Pentamethylquercetin Attenuates Cardiac Remodeling via Activation of the SestrinsKeap1Nrf2 Pathway in MSG-Induced Obese Mice
Joint Authors
Du, Jingxia
He, Wei
Zhang, Cai
Wu, Jianzhao
Li, Zhi
Wang, Min
Feng, Shuying
Liang, Gaofeng
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-01-31
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Objective.
Obesity causes a variety of metabolic alterations that may contribute to abnormalities of the cardiac structure and function (obesity cardiomyopathy).
In previous works, we have shown that pentamethylquercetin (PMQ) significantly improved metabolic disorders in obese mice and it inhibited pressure overload-induced cardiac remodeling in mice.
However, its potential benefit in obesity cardiomyopathy remains unclear.
The aim of this study was to investigate the effects of PMQ on cardiac remodeling in obese mice.
Methods.
We generated a monosodium glutamate-induced obese (MSG-IO) model in mice, which were treated with PMQ (5, 10, and 20 mg/kg) for 16 weeks consecutively.
We examined the metabolic parameters and observed cardiac remodeling by performing cardiac echocardiography and Masson’s staining.
The expression levels of molecules associated with the endogenous antioxidant system, including the sestrins/kelch-like ECH-associated protein 1 (Keap1)/Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) signaling pathway, were analyzed by western blotting and immunofluorescent staining.
Results.
We found that PMQ treatment significantly ameliorated obesity phenotypes and improved metabolic disorders in MSG-IO mice.
PMQ decreased the heart wall thickness and attenuated cardiac fibrosis.
Further study revealed that the protective effects of PMQ might be mediated by promoting Keap1 degradation and augmenting sestrins expression and Nrf2 nuclear translocation.
Conclusion.
Our findings indicated that PMQ ameliorated cardiac remodeling in obese mice by targeting the sestrins/Keap1/Nrf2 signaling pathway.
American Psychological Association (APA)
Du, Jingxia& He, Wei& Zhang, Cai& Wu, Jianzhao& Li, Zhi& Wang, Min…[et al.]. 2020. Pentamethylquercetin Attenuates Cardiac Remodeling via Activation of the SestrinsKeap1Nrf2 Pathway in MSG-Induced Obese Mice. BioMed Research International،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1133090
Modern Language Association (MLA)
Du, Jingxia…[et al.]. Pentamethylquercetin Attenuates Cardiac Remodeling via Activation of the SestrinsKeap1Nrf2 Pathway in MSG-Induced Obese Mice. BioMed Research International No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1133090
American Medical Association (AMA)
Du, Jingxia& He, Wei& Zhang, Cai& Wu, Jianzhao& Li, Zhi& Wang, Min…[et al.]. Pentamethylquercetin Attenuates Cardiac Remodeling via Activation of the SestrinsKeap1Nrf2 Pathway in MSG-Induced Obese Mice. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1133090
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1133090