The Role of Overexpressed Apolipoprotein AV in Insulin-Resistant Hepatocytes
Joint Authors
Zhao, Wang
Liu, Yaqiong
Liao, Xiaobo
Zhao, Shuiping
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-04-22
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
In this paper, we sought to explore the relationship between apolipoprotein AV (APOAV) overexpression and insulin resistance in hepatocytes.
The insulin-resistant HepG2 cell model was constructed, and then, APOAV-overexpressed HepG2 cells (B-M) were induced by infecting with a recombinant adenovirus vector.
Microarray data were developed from B-M samples compared with negative controls (A-con), and the microarray data were analyzed by bioinformatic methods.
APOAV-overexpression induced 313 upregulated genes and 563 downregulated ones in B-M sample.
The differentially expressed genes (DEGs) were significantly classified in fat digestion and absorption pathway.
Protein-protein interaction network was constructed, and AGTR1 (angiotensin II receptor type 1) and P2RY2 (purinergic receptor P2Y, G-protein coupled 2) were found to be the significant nodes closely related with G-protein related signaling.
Additionally, overexpression of APOAV could change the expression of Glut4 and release the insulin resistance of hepatic cells.
Thus, APOAV overexpression may prevent the insulin resistance in liver cells by mediating the genes such as AGTR1 and P2RY2.
American Psychological Association (APA)
Zhao, Wang& Liu, Yaqiong& Liao, Xiaobo& Zhao, Shuiping. 2020. The Role of Overexpressed Apolipoprotein AV in Insulin-Resistant Hepatocytes. BioMed Research International،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1133109
Modern Language Association (MLA)
Zhao, Wang…[et al.]. The Role of Overexpressed Apolipoprotein AV in Insulin-Resistant Hepatocytes. BioMed Research International No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1133109
American Medical Association (AMA)
Zhao, Wang& Liu, Yaqiong& Liao, Xiaobo& Zhao, Shuiping. The Role of Overexpressed Apolipoprotein AV in Insulin-Resistant Hepatocytes. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1133109
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1133109