Dynamic Modeling of the Angiogenic Switch and Its Inhibition by Bevacizumab
Joint Authors
Kovács, Levente
Csercsik, Dávid
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-01-03
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
We formulate a dynamic model of vascular tumor growth, in which the interdependence of vascular dynamics with tumor volume is considered.
The model describes the angiogenic switch; thus the inhibition of the vascularization process by antiangiogenic drugs may be taken into account explicitly.
We validate the model against volume measurement data originating from experiments on mice and analyze the model behavior assuming different inputs corresponding to different therapies.
Furthermore, we show that a simple extension of the model is capable of considering cytotoxic and antiangiogenic drugs as inputs simultaneously in qualitatively different ways.
American Psychological Association (APA)
Csercsik, Dávid& Kovács, Levente. 2019. Dynamic Modeling of the Angiogenic Switch and Its Inhibition by Bevacizumab. Complexity،Vol. 2019, no. 2019, pp.1-18.
https://search.emarefa.net/detail/BIM-1133123
Modern Language Association (MLA)
Csercsik, Dávid& Kovács, Levente. Dynamic Modeling of the Angiogenic Switch and Its Inhibition by Bevacizumab. Complexity No. 2019 (2019), pp.1-18.
https://search.emarefa.net/detail/BIM-1133123
American Medical Association (AMA)
Csercsik, Dávid& Kovács, Levente. Dynamic Modeling of the Angiogenic Switch and Its Inhibition by Bevacizumab. Complexity. 2019. Vol. 2019, no. 2019, pp.1-18.
https://search.emarefa.net/detail/BIM-1133123
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1133123