Antioxidant and Anti-Inflammatory Effects of Different Zinc Sources on Diquat-Induced Oxidant Stress in a Piglet Model
Joint Authors
Guan, Guiping
Yin, Yulong
Yin, Jie
He, Liuqin
Guo, Jieping
Li, T. J.
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-03-21
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Zinc (Zn) plays a crucial role in reducing oxidative stress and diarrhea in postweanling piglets.
This study is aimed at comparing the effects of zinc chelate of 2-hydroxy-4 methyl-thio butanoic acid (HMZn) and ZnSO4 on the oxidative stress in weaned piglets.
A total of 32 piglets were randomly divided into 4 treatments: CON: basal diet+80 mg/kg Zn as ZnSO4; DIQ: basal diet+80 mg/kg Zn as ZnSO4; HMZn: basal diet+200 mg/kg Zn as HMZn; and ZnSO4: basal diet+200 mg/kg Zn as ZnSO4.
On day 15, the DIQ, HMZn, and ZnSO4 groups were injected intraperitoneally with diquat except for the CON group.
The trial lasted 21 days.
The results showed that zinc sources did not influence the growth performance during the first 14 days.
But HMZn increased activities of superoxide dismutase (SOD), glutathione peroxidase (GPX), and total antioxidant capacity (T-AOC) in serum (P<0.05).
After diquat injection, the fecal score was decreased in the HMZn group.
Both HMZn and ZnSO4 increased the activities of GPX and T-AOC in serum and the relative mRNA expressions of hepatic and renal Nrf2, SOD1, and GPX compared with the DIQ group (P<0.05).
Moreover, the relative mRNA expression of inflammatory factors in the small intestine, liver, and kidney was downregulated; the phosphorylation of NF-κB protein was inhibited in the HMZn group compared with the DIQ and ZnSO4 groups (P<0.05).
In general, HMZn showed notable advantage over ZnSO4 in reducing diarrhea and improving antioxidant and anti-inflammatory ability in piglets challenged with diquat.
American Psychological Association (APA)
Guo, Jieping& He, Liuqin& Li, T. J.& Yin, Jie& Yin, Yulong& Guan, Guiping. 2020. Antioxidant and Anti-Inflammatory Effects of Different Zinc Sources on Diquat-Induced Oxidant Stress in a Piglet Model. BioMed Research International،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1133180
Modern Language Association (MLA)
Guo, Jieping…[et al.]. Antioxidant and Anti-Inflammatory Effects of Different Zinc Sources on Diquat-Induced Oxidant Stress in a Piglet Model. BioMed Research International No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1133180
American Medical Association (AMA)
Guo, Jieping& He, Liuqin& Li, T. J.& Yin, Jie& Yin, Yulong& Guan, Guiping. Antioxidant and Anti-Inflammatory Effects of Different Zinc Sources on Diquat-Induced Oxidant Stress in a Piglet Model. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1133180
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1133180