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Recombinant Lactococcus lactis Expressing Ling Zhi 8 Protein Ameliorates Nonalcoholic Fatty Liver and Early Atherogenesis in Cholesterol-Fed Rabbits
Joint Authors
Lee, Mey-Fann
Chiang, Chu-Hui
Lin, Shyh-Jye
Song, Pei-Pong
Liu, Hsin-Chun
Wu, Tsu-Juey
Lin, Wei-Wen
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-01-27
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Atherosclerosis is an inflammatory disease characterized by lipid deposits in the subendothelial space leading to severe inflammation.
Nonalcoholic fatty liver disease (NAFLD) shares several risk factors with atherosclerosis, including dyslipidemia, type 2 diabetes mellitus, and metabolic syndrome, all of which lead to lipid deposition in the liver causing inflammation and fibrosis.
Several clinical trials have shown that certain Chinese herbal medicines with anti-inflammatory effects can be used as adjuvant therapy to prevent the development of cardiovascular events and liver disease.
Ling Zhi 8 (LZ8) is an immunomodulatory protein isolated from a medicinal mushroom and has been well documented to possess a broad range of pharmacological properties.
This study aimed to evaluate the protective effects of recombinant Lactococcus lactis expressing LZ8 protein on NAFLD and atherogenesis in a cholesterol-fed rabbit model.
Twelve rabbits were divided into three groups and fed with syrup only, L.
lactis vehicle, or recombinant L.
lactis-LZ8 once a day on weekdays for five weeks, respectively.
The gene expression of IL-1β in the aorta was significantly suppressed after oral administration of L.
lactis-LZ8.
Moreover, in hematoxylin and eosin staining of the aorta, the intima-medial thickness was decreased, and foam cells were significantly reduced in the subendothelial space.
LZ8 also inhibited the expression of IL-1β in the liver, decreased fat droplet deposits and infiltration of inflammatory cells, and improved liver function by decreasing liver enzymes in an animal model.
Our results suggest that the Lactococcus-expressing LZ8 appears to be a promising medicine for improving both NAFLD and early atherogenesis owing to its anti-inflammatory effect.
Furthermore, it is available as a low-cost food-grade product.
American Psychological Association (APA)
Lee, Mey-Fann& Chiang, Chu-Hui& Lin, Shyh-Jye& Song, Pei-Pong& Liu, Hsin-Chun& Wu, Tsu-Juey…[et al.]. 2020. Recombinant Lactococcus lactis Expressing Ling Zhi 8 Protein Ameliorates Nonalcoholic Fatty Liver and Early Atherogenesis in Cholesterol-Fed Rabbits. BioMed Research International،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1133222
Modern Language Association (MLA)
Lee, Mey-Fann…[et al.]. Recombinant Lactococcus lactis Expressing Ling Zhi 8 Protein Ameliorates Nonalcoholic Fatty Liver and Early Atherogenesis in Cholesterol-Fed Rabbits. BioMed Research International No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1133222
American Medical Association (AMA)
Lee, Mey-Fann& Chiang, Chu-Hui& Lin, Shyh-Jye& Song, Pei-Pong& Liu, Hsin-Chun& Wu, Tsu-Juey…[et al.]. Recombinant Lactococcus lactis Expressing Ling Zhi 8 Protein Ameliorates Nonalcoholic Fatty Liver and Early Atherogenesis in Cholesterol-Fed Rabbits. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1133222
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1133222