The Development of Three-DNA Methylation Signature as a Novel Prognostic Biomarker in Patients with Colorectal Cancer
Joint Authors
Gong, Shu
Ye, Weijian
Liu, Tiankai
Jian, Shaofen
Liu, Wenhua
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-26
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Aims.
The prognosis of colorectal cancer (CRC) remains poor.
This study aimed to develop and validate DNA methylation-based signature model to predict overall survival of CRC patients.
Methods.
The methylation array data of CRC patients were retrieved from The Cancer Genome Atlas (TCGA) database.
These patients were divided into training and validation datasets.
A risk score model was established based on Kaplan-Meier and multivariate Cox regression analysis of training cohort and tested in validation cohort.
Results.
Among total 14,626 DNA methylation candidate markers, we found that a three-DNA methylation signature (NR1H2, SCRIB, and UACA) was significantly associated with overall survival of CRC patients.
Subgroup analysis indicated that this signature could predict overall survival of CRC patients regardless of age and gender.
Conclusions.
We established a prognostic model consisted of 3-DNA methylation sites, which could be used as potential biomarker to evaluate the prognosis of CRC patients.
American Psychological Association (APA)
Gong, Shu& Ye, Weijian& Liu, Tiankai& Jian, Shaofen& Liu, Wenhua. 2020. The Development of Three-DNA Methylation Signature as a Novel Prognostic Biomarker in Patients with Colorectal Cancer. BioMed Research International،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1133228
Modern Language Association (MLA)
Gong, Shu…[et al.]. The Development of Three-DNA Methylation Signature as a Novel Prognostic Biomarker in Patients with Colorectal Cancer. BioMed Research International No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1133228
American Medical Association (AMA)
Gong, Shu& Ye, Weijian& Liu, Tiankai& Jian, Shaofen& Liu, Wenhua. The Development of Three-DNA Methylation Signature as a Novel Prognostic Biomarker in Patients with Colorectal Cancer. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1133228
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1133228