Pharmacogenetic Association between XRCC1 Polymorphisms and Response to Platinum-Based Chemotherapy in Asian Patients with NSCLC: A Meta-Analysis
Joint Authors
Zhang, Ningning
Ouyang, Yushu
Chang, Jianlan
Liu, Ping
Tian, Xiangyang
Yu, Junyan
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-10-23
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Background.
Platinum-based chemotherapy plays an antitumor role by damaging DNA.
X-ray repair crosscomplementing protein 1 (XRCC1) participates in DNA repair and thus affects the sensitivity to platinum drugs.
Two polymorphisms of XRCC1, rs25487 (Arg399Gln) and rs1799782 (Arg194Trp), have been widely studied for the association with clinical outcomes of platinum-based chemotherapy in Asian patients with non-small-cell lung cancer (NSCLC), but the results remain inconclusive.
Thus, we performed the present meta-analysis.
Methods.
Literature search was performed in PubMed, Web of Science, and EMBASE up to June 2019.
Odds ratios (ORs) for objective response ratio (ORR), Cox proportional hazard ratios (HRs) of overall survival (OS) and progression-free survival (PFS), and the corresponding 95% confidence intervals (95% CIs) were calculated to assess the association strengths between XRCC1 polymorphisms and clinical outcomes.
Comparisons were performed in homozygous, heterozygous, dominant, and recessive models.
Results.
Finally, a total of 23 studies involving 5567 patients were included in the meta-analysis.
Compared to ArgArg of rs25487, GlnGln (OR=1.71, 95% CI: 1.16-2.52, p=.007, I2=56.8%) and GlnArg (OR=1.23, 95% CI: 1.07-1.40, p=.003, I2=29.0%) were associated with higher ORR.
Meanwhile, GlnGln indicated a favorable OS (HR=0.60, 95% CI: 0.40-0.88) and PFS (HR=0.64, 95% CI: 0.46-0.90).
We also found positive associations between rs1799782 and ORR in all comparison models with low between-study heterogeneity.
The association strength increased with the number of variant alleles (TrpTrp vs.
ArgArg: OR=1.73, 95% CI:1.31-2.27; TrpArg vs.
ArgArg: OR=1.28, 95% CI: 1.06-1.55), suggesting a gene dosage effect.
In addition, TrpTrp predicted a longer OS.
Conclusion.
Our results showed that rs25487 and rs1799782 of XRCC1 are potential markers to predict clinical outcomes of platinum-based chemotherapy in Asian patients with NSCLC.
American Psychological Association (APA)
Zhang, Ningning& Ouyang, Yushu& Chang, Jianlan& Liu, Ping& Tian, Xiangyang& Yu, Junyan. 2020. Pharmacogenetic Association between XRCC1 Polymorphisms and Response to Platinum-Based Chemotherapy in Asian Patients with NSCLC: A Meta-Analysis. BioMed Research International،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1133250
Modern Language Association (MLA)
Zhang, Ningning…[et al.]. Pharmacogenetic Association between XRCC1 Polymorphisms and Response to Platinum-Based Chemotherapy in Asian Patients with NSCLC: A Meta-Analysis. BioMed Research International No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1133250
American Medical Association (AMA)
Zhang, Ningning& Ouyang, Yushu& Chang, Jianlan& Liu, Ping& Tian, Xiangyang& Yu, Junyan. Pharmacogenetic Association between XRCC1 Polymorphisms and Response to Platinum-Based Chemotherapy in Asian Patients with NSCLC: A Meta-Analysis. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1133250
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1133250