Exosomal MicroRNAs in Serum as Potential Biomarkers for Ectopic Pregnancy
Joint Authors
Sun, Jianhua
Deng, Gaopi
Ruan, Xiaofeng
Chen, Si
Liao, Huiyan
Liu, Xiaorong
Li, Jing
Zhao, Guang
Gao, Jie
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-06-11
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Design.
From July 2016 to June 2018, 36 women with symptomatic early pregnancy around 4-8 weeks of gestation were recruited into the study.
Among them, there were 16 women with viable intrauterine pregnancy (VIP), 9 women with spontaneous abortion (SA), and 11 women of EP.
Serum exosomal miRNAs were extracted and measured at the first prenatal visit.
Statistical analysis was performed to determine the clinical utility of these biomarkers as single markers and as multimarker panels for EP.
Results.
Concentrations of miR-378d in serum exosomes were significantly higher in EP than in VIP and also SA group.
As a single marker, miR-378d had the highest specificity of 64% at the sensitivity of 89.1%.
Comparatively, both combined panels of hCG, progesterone, miR-100-5p and hCG, progesterone, and miR-215-5P yielded the specificity of 96%.
Panels for all markers achieved the highest specificity of 80% at the sensitivity of 91%.
Conclusions.
Although further validation in large-scale prospective studies is necessary, our results suggest that serum exosomal miR-378d, miR-100-5p, and miR-215-5P are promising biomarkers for early EP.
American Psychological Association (APA)
Sun, Jianhua& Deng, Gaopi& Ruan, Xiaofeng& Chen, Si& Liao, Huiyan& Liu, Xiaorong…[et al.]. 2020. Exosomal MicroRNAs in Serum as Potential Biomarkers for Ectopic Pregnancy. BioMed Research International،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1133252
Modern Language Association (MLA)
Sun, Jianhua…[et al.]. Exosomal MicroRNAs in Serum as Potential Biomarkers for Ectopic Pregnancy. BioMed Research International No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1133252
American Medical Association (AMA)
Sun, Jianhua& Deng, Gaopi& Ruan, Xiaofeng& Chen, Si& Liao, Huiyan& Liu, Xiaorong…[et al.]. Exosomal MicroRNAs in Serum as Potential Biomarkers for Ectopic Pregnancy. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1133252
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1133252