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Deterioration of Health-Related Quality of Life Scores under Treatment Predicts Longer Survival
Joint Authors
Fietkau, Rainer
Distel, Luitpold V.
Hecht, Markus
Jörling, Maike
Rutzner, Sandra
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-08-17
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Objectives.
Baseline health-related quality of life (HRQoL) scores predict survival, which has already been demonstrated in various studies.
However, we were interested in whether changes in baseline scores during treatment are also significant predictors of survival.
Methods and Materials.
We analysed the data of 400 consecutive cancer patients receiving radiochemotherapy.
Leading diagnoses were head and neck cancer (34.5%), rectal cancer (24.5%), and lung cancer (13%).
HRQoL was studied at baseline, six weeks after therapy and after each completed year after the start of therapy until drop out of the study using the EORTC QLQ-C30 questionnaire.
The change score was calculated as the baseline score subtracted from the score after therapy.
Statistics included Kaplan-Meier estimates and Cox regression.
Results.
High global health status (p=0.005) and low pain scores (p=0.040) at baseline were related to favourable overall survival.
Change scores of role functioning (p=0.027), global health status (p<0.018), and pain (p<0.001) were predictive of overall survival.
Pain was the superior predictor of survival (p=0.001) among all variables and QoL scores studied by multivariate analysis.
A deterioration in pain was associated with a 2.8 times higher chance of survival (HR 0.36).
Conclusions.
Deterioration of HRQoL baseline pain score by cancer treatment is a favourable and superior prognostic factor for survival.
American Psychological Association (APA)
Jörling, Maike& Rutzner, Sandra& Hecht, Markus& Fietkau, Rainer& Distel, Luitpold V.. 2020. Deterioration of Health-Related Quality of Life Scores under Treatment Predicts Longer Survival. BioMed Research International،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1133294
Modern Language Association (MLA)
Jörling, Maike…[et al.]. Deterioration of Health-Related Quality of Life Scores under Treatment Predicts Longer Survival. BioMed Research International No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1133294
American Medical Association (AMA)
Jörling, Maike& Rutzner, Sandra& Hecht, Markus& Fietkau, Rainer& Distel, Luitpold V.. Deterioration of Health-Related Quality of Life Scores under Treatment Predicts Longer Survival. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1133294
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1133294