Alpha-Defensin versus Leukocyte Esterase in Periprosthetic Joint Infection: An Updated Meta-Analysis
Joint Authors
Gao, Fuqiang
Zhang, Qingyu
Li, Zirong
Shi, Lijun
Li, Zhizhuo
Sun, Wei
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-18
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Periprosthetic joint infection (PJI) is a devastating complication after arthroplasty.
Prompt establishment of an infection diagnosis is critical but can be very challenging at present.
In order to evaluate the diagnostic accuracy of alpha-defensin or leukocyte esterase for PJI, we performed systematic research in PubMed, Embase, and Cochrane Library to retrieve relevant studies.
Data extraction and quality assessment were performed by two reviewers independently.
A total of thirty-one eligible studies were finally included in the quantitative analysis.
The pooled sensitivity and specificity of alpha-defensin (21 studies) for the diagnosis of PJI were 0.89 (95% confidence interval (CI), 0.83 to 0.93) and 0.96 (95% CI, 0.95 to 0.97), respectively.
The value of the pooled diagnostic odds ratios (DOR) of alpha-defensin for PJI was 209.14 (95% CI, 97.31 to 449.50), and the area under the curve (AUC) was 0.98 (95% CI, 0.96 to 0.99).
The pooled sensitivity and specificity of leukocyte esterase (17 studies) for the diagnosis of PJI were 0.90 (95% CI, 0.84 to 0.95) and 0.96 (95% CI, 0.93 to 0.97), respectively.
The value of the DOR of leukocyte esterase for PJI was 203.23 (95% CI, 96.14 to 429.61), and the AUC was 0.98 (95% CI, 0.96 to 0.99).
Based on the results of our meta-analysis, we can conclude that alpha-defensin and leukocyte esterase are valuable synovial fluid markers for identifying PJI with comparable high diagnostic accuracy.
American Psychological Association (APA)
Li, Zhizhuo& Zhang, Qingyu& Shi, Lijun& Gao, Fuqiang& Sun, Wei& Li, Zirong. 2020. Alpha-Defensin versus Leukocyte Esterase in Periprosthetic Joint Infection: An Updated Meta-Analysis. BioMed Research International،Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1133391
Modern Language Association (MLA)
Li, Zhizhuo…[et al.]. Alpha-Defensin versus Leukocyte Esterase in Periprosthetic Joint Infection: An Updated Meta-Analysis. BioMed Research International No. 2020 (2020), pp.1-14.
https://search.emarefa.net/detail/BIM-1133391
American Medical Association (AMA)
Li, Zhizhuo& Zhang, Qingyu& Shi, Lijun& Gao, Fuqiang& Sun, Wei& Li, Zirong. Alpha-Defensin versus Leukocyte Esterase in Periprosthetic Joint Infection: An Updated Meta-Analysis. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1133391
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1133391