Research Status of Differentially Expressed Noncoding RNAs in Type 2 Diabetes Patients
Joint Authors
Shi, Rou
Chen, Yingjian
Liao, Yuanjun
Li, Rang
Lin, Chunwen
Xiu, Liangchang
Yu, Haibing
Ding, Yuanlin
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-16
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
Aims.
Noncoding RNAs (ncRNAs) play an important role in the occurrence and development of type 2 diabetes mellitus (T2DM).
This paper summarized the current evidences of the involvement microRNAs, long noncoding RNAs (lncRNAs), and circular RNAs (circRNAs) in the differential expressions and their interaction with each other in T2DM.
Methods.
The differentially expressed miRNAs, lncRNAs, and circRNAs in the blood circulation (plasma, serum, whole blood, and peripheral blood mononuclear cells) of patients with T2DM were found in PubMed, GCBI, and other databases.
The interactions between ncRNAs were predicted based on the MiRWalk and the DIANA Tools databases.
The indirect and direct target genes of lncRNAs and circRNAs were predicted based on the starBase V2.0, DIANA Tools, and LncRNA-Target databases.
Then, GO and KEGG analysis on all miRNA, lncRNA, and circRNA target genes was performed using the mirPath and Cluster Profile software package in R language.
The lncRNA–miRNA and circRNA–miRNA interaction diagram was constructed with Cytoscape.
The aim of this investigation was to construct a mechanism diagram of lncRNA involved in the regulation of target genes on insulin signaling pathways and AGE–RAGE signaling pathways of diabetic complications.
Results.
A total of 317 RNAs, 283 miRNAs, and 20 lncRNAs and circRNAs were found in the circulation of T2DM.
Dysregulated microRNAs and lncRNAs were found to be involved in signals related to metabolic disturbances, insulin signaling, and AGE–RAGE signaling in T2DM.
In addition, lncRNAs participate in the regulation of key genes in the insulin signaling and AGE–RAGE signaling pathways through microRNAs, which leads to insulin resistance and diabetic vascular complications.
Conclusion.
Noncoding RNAs participate in the occurrence and development of type 2 diabetes and lead to its vascular complications by regulating different signaling pathways.
American Psychological Association (APA)
Shi, Rou& Chen, Yingjian& Liao, Yuanjun& Li, Rang& Lin, Chunwen& Xiu, Liangchang…[et al.]. 2020. Research Status of Differentially Expressed Noncoding RNAs in Type 2 Diabetes Patients. BioMed Research International،Vol. 2020, no. 2020, pp.1-18.
https://search.emarefa.net/detail/BIM-1133452
Modern Language Association (MLA)
Shi, Rou…[et al.]. Research Status of Differentially Expressed Noncoding RNAs in Type 2 Diabetes Patients. BioMed Research International No. 2020 (2020), pp.1-18.
https://search.emarefa.net/detail/BIM-1133452
American Medical Association (AMA)
Shi, Rou& Chen, Yingjian& Liao, Yuanjun& Li, Rang& Lin, Chunwen& Xiu, Liangchang…[et al.]. Research Status of Differentially Expressed Noncoding RNAs in Type 2 Diabetes Patients. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-18.
https://search.emarefa.net/detail/BIM-1133452
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1133452