Ginsenoside Rb1 Improves Cognitive Impairment Induced by Insulin Resistance through Cdk5p35-NMDAR-IDE Pathway
Joint Authors
Yang, Ranyao
Jiang, Xue
He, Xiqian
Liang, Donglou
Sun, Shusen
Zhou, Guangyan
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-05-20
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The relationship between diabetes mellitus (DM) and Alzheimer’s disease (AD) has attracted wide attention.
Studies have reported that ginsenoside Rb1 can improve human cognitive ability and glucose tolerance during the development of diabetes.
The mechanism behind the improvement in cognitive ability and glucose tolerance still remains unclear.
In this study, streptozotocin- (STZ-) injected mice were used as models to explore the mechanisms behind the cognitive improvement of ginsenoside Rb1.
According to the results of behavioral tests, ginsenoside Rb1 improved memory and cognitive ability of STZ-lesioned mice.
In addition to that, ginsenoside Rb1 also relieved glucose intolerance induced by STZ injection by enhancing insulin sensitivity.
These beneficial effects of ginsenoside Rb1 is most likely mediated by upregulating the expression of NMDAR1 and IDE in the hippocampus through inhibiting the activity of Cdk5/p35.
This work will be of great importance in illustrating the mechanisms of ginsenoside Rb1 for improving cognitive ability, as well as revealing the relationship between diabetes and AD.
American Psychological Association (APA)
Yang, Ranyao& Jiang, Xue& He, Xiqian& Liang, Donglou& Sun, Shusen& Zhou, Guangyan. 2020. Ginsenoside Rb1 Improves Cognitive Impairment Induced by Insulin Resistance through Cdk5p35-NMDAR-IDE Pathway. BioMed Research International،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1133536
Modern Language Association (MLA)
Yang, Ranyao…[et al.]. Ginsenoside Rb1 Improves Cognitive Impairment Induced by Insulin Resistance through Cdk5p35-NMDAR-IDE Pathway. BioMed Research International No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1133536
American Medical Association (AMA)
Yang, Ranyao& Jiang, Xue& He, Xiqian& Liang, Donglou& Sun, Shusen& Zhou, Guangyan. Ginsenoside Rb1 Improves Cognitive Impairment Induced by Insulin Resistance through Cdk5p35-NMDAR-IDE Pathway. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1133536
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1133536