Clinical Characteristics of 162 Patients with Drug-Induced Liver andor Kidney Injury

Abstract EN

Context.

Drug-induced liver and kidney injuries are the most common adverse drug reactions in the clinic, and they have similar pathogeneses.

Aims.

To analyze the clinical characteristics of patients with drug-induced liver and/or kidney injury.

Settings and Design.

This was a retrospective study.

Methods and Materials.

We analyzed data from 162 patients with drug-induced liver and/or kidney injury from 2008 to 2018 at the Chinese Rocket Force Characteristic Medical Center.

Univariate and multivariate logistic analyses were performed on the drugs used, sex, age, weight, complications, and laboratory test results.

Statistical analysis was performed using SPSS 25.0 statistical software.

Results.

(1) The most common drugs causing organ injury in this study were antineoplastic drugs, antibiotics, traditional Chinese medicine, lipid-lowering drugs, and nonsteroidal anti-inflammatory drugs.

(2) Among 22 patients with drug-induced liver and kidney injuries, 68.18% had a hepatocellular pattern, 13.64% had a mixed pattern, and 18.18% had a cholestatic pattern.

Among the three groups, the P value for creatinine was 0.002.

(3) The P value for urinary protein between the isolated kidney injury group and the liver and kidney injury group was 0.028.

(4) Multivariate analysis showed that, among the drug-induced renal injury patients and all injury patients, those with a higher neutrophil percentage had a lower risk of liver injury (OR = 0.574, 95% CI: 0.390–0.846; OR = 0.545, 95% CI: 0.396–0.749).

Conclusions.

(1) The serum creatinine level was higher in liver injury patients with the cholestatic pattern than in those with the hepatocellular or mixed pattern.

(2) There was a significant difference in urinary protein between the isolated kidney and the liver and kidney injury groups.

(3) Among patients with drug-induced organ injury, those with a higher neutrophils percentage had a lower risk of liver injury.