![](/images/graphics-bg.png)
TPPP3 Associated with Prognosis and Immune Infiltrates in Head and Neck Squamous Carcinoma
Joint Authors
Yang, Zheng
Li, Jingyu
Zhang, Liqian
Zhang, Zunni
Qiu, Yuling
Su, Qisheng
Mo, Wuning
Li, Xiaohong
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-10-07
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Tubulin polymerization promoting protein family member 3 (TPPP3) is a kind of protein that can mediate the dynamics and stability of microtubules.
However, the correlations of TPPP3 between prognosis and immune infiltrates in different tumors are still unclear.
The analysis of TPPP3 expression was performed via Oncomine and Gene Expression Profiling Interactive Analysis (GEPIA) website.
We also used GEPIA to assess the impact of TPPPT3 on clinical outcomes.
The related pathways involved in TPPP3 were analyzed by gene-set enrichment analysis (GSEA), and the correlation between TPPP3 and immune infiltration was studied by Tumor Immune Estimation Resource2.0 (TIMER 2.0).
The TPPP3 expression was significantly reduced in head and neck squamous carcinoma (HNSC) compared to adjacent tissues.
In addition, the low expression of TPPP3 in HNSC was significantly associated with prognosis.
The pathways closely related to the low expression of TPPP3 are “Antigen Processing and Presentation,” “Primary Immunodeficiency,” and so on.
The TPPP3 expression was negatively correlated with the level of CD8+ T cell, B cell, and myeloid dendritic cell infiltration in HNSC.
The TPPP3 expression is closely related to multiple immunomarkers in CD8+ T cell and Myeloid dendritic cells.
These data indicate that TPPP3 is associated with multiple cancers and involves multiple immune-related pathways, and TPPP3 is associated with immune infiltration levels.
Besides, the TPPP3 expression may help regulate tumor-associated CD8 + T cells, DC cells in HNSC.
We conclude TPPP3 can be considered as a biomarker for predicting head and neck squamous cell carcinoma prognosis and immune infiltration.
American Psychological Association (APA)
Yang, Zheng& Li, Xiaohong& Li, Jingyu& Su, Qisheng& Qiu, Yuling& Zhang, Zunni…[et al.]. 2020. TPPP3 Associated with Prognosis and Immune Infiltrates in Head and Neck Squamous Carcinoma. BioMed Research International،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1133562
Modern Language Association (MLA)
Yang, Zheng…[et al.]. TPPP3 Associated with Prognosis and Immune Infiltrates in Head and Neck Squamous Carcinoma. BioMed Research International No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1133562
American Medical Association (AMA)
Yang, Zheng& Li, Xiaohong& Li, Jingyu& Su, Qisheng& Qiu, Yuling& Zhang, Zunni…[et al.]. TPPP3 Associated with Prognosis and Immune Infiltrates in Head and Neck Squamous Carcinoma. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1133562
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1133562