Muscle Fatigue-Alleviating Effects of a Prescription Composed of Polygonati Rhizoma and Notoginseng Radix et Rhizoma
Joint Authors
Yu, Jie
Yang, Xingxin
Mu, Jian-Kang
Yang, Ya-Qin
Li, Yan-Qin
Yu, Li-Ping
Li, Xue
Shang, Jin
Gu, Wen
Li, Jing-Ping
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-06-09
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Long-term muscle fatigue is a major cause of injury.
Drugs/nutrients from herbal medicines that prevent fatigue remain a major research focus.
In China, a prescription composed of Polygonati Rhizoma and Notoginseng Radix et Rhizoma has been commonly used as a herb and food nutrient, providing protection against fatigue in the clinic.
To date, the mechanisms through which this prescription prevented fatigue are unknown.
Here, we identified the effects of this prescription on muscle fatigue based on energy and oxidation regulation.
Fatigue mouse models were produced through weight-bearing exhaustive swimming.
Mice were intragastrically administered prescription extracts (1 and 2 g/kg) for four weeks.
Changes in exhaustive swimming times, antifatigue biochemical indicators, oxidative status, and energy metabolism were investigated.
The prescription prolonged the exhaustive swimming time of the mice.
The content of lactic acid and blood urea nitrogen in the serum was also markedly reduced by the prescription.
The content of liver glycogen and lactate dehydrogenase in the serum increased.
The prescription also significantly reduced malondialdehyde levels and increased the levels of superoxide dismutase and glutathione peroxidase.
The levels of ATPase, complexes I and II in the mitochondria of hind-leg skeletal muscle, and serum creatine kinase also increased in response to the prescription.
Our results indicated that the prescription could effectively alleviate muscle fatigue status by promoting energy metabolism and antioxidation ability.
The prescription therefore represents a useful drug/nutrient strategy to alleviate muscle fatigue.
American Psychological Association (APA)
Yang, Ya-Qin& Li, Yan-Qin& Yu, Li-Ping& Li, Xue& Mu, Jian-Kang& Shang, Jin…[et al.]. 2020. Muscle Fatigue-Alleviating Effects of a Prescription Composed of Polygonati Rhizoma and Notoginseng Radix et Rhizoma. BioMed Research International،Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1133569
Modern Language Association (MLA)
Yang, Ya-Qin…[et al.]. Muscle Fatigue-Alleviating Effects of a Prescription Composed of Polygonati Rhizoma and Notoginseng Radix et Rhizoma. BioMed Research International No. 2020 (2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1133569
American Medical Association (AMA)
Yang, Ya-Qin& Li, Yan-Qin& Yu, Li-Ping& Li, Xue& Mu, Jian-Kang& Shang, Jin…[et al.]. Muscle Fatigue-Alleviating Effects of a Prescription Composed of Polygonati Rhizoma and Notoginseng Radix et Rhizoma. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1133569
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1133569