Screening and Functional Analysis of Hub MicroRNAs Related to Tumor Development in Colon Cancer
Joint Authors
Li, Sheng
Yu, Dong-Hu
Li, Wei
Huang, Jing-Yu
Liu, Xiao-Ping
Zhang, Chi
Ruan, Xiao-Lan
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-01-23
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Various microRNAs (miRNAs) are of importance in the development of colon cancer, but most of the mechanisms of the miRNAs are still unclear.
In order to clarify the hub miRNAs and their roles in colon cancer development, GSE98406 was used to screen hub miRNAs by bioinformatics analysis.
46 DE-miRNAs (14 were upregulated and 32 were downregulated) and 1738 target genes of DE-miRNAs were ascertained.
miRNAs-gene-networks and miRNAs-GO-networks were built to get more knowledge about the function of candidate miRNAs.
After validation, three miRNAs (miR-17-5p, miR-182-5p and miR-200a-3p) were recognized to be hub miRNAs associated with the progression of colon cancer.
More importantly, the hub miRNAs and the putative targets genes might be new diagnostic and therapeutic targets for colon cancer in the future.
American Psychological Association (APA)
Yu, Dong-Hu& Li, Wei& Huang, Jing-Yu& Liu, Xiao-Ping& Zhang, Chi& Ruan, Xiao-Lan…[et al.]. 2020. Screening and Functional Analysis of Hub MicroRNAs Related to Tumor Development in Colon Cancer. BioMed Research International،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1133595
Modern Language Association (MLA)
Yu, Dong-Hu…[et al.]. Screening and Functional Analysis of Hub MicroRNAs Related to Tumor Development in Colon Cancer. BioMed Research International No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1133595
American Medical Association (AMA)
Yu, Dong-Hu& Li, Wei& Huang, Jing-Yu& Liu, Xiao-Ping& Zhang, Chi& Ruan, Xiao-Lan…[et al.]. Screening and Functional Analysis of Hub MicroRNAs Related to Tumor Development in Colon Cancer. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1133595
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1133595