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Preconditioning Effect of High-Intensity Interval Training (HIIT) and Berberine Supplementation on the Gene Expression of Angiogenesis Regulators and Caspase-3 Protein in the Rats with Myocardial Ischemia-Reperfusion (IR) Injury
Joint Authors
Banaei, Parisa
Nazem, Farzad
Nazari, Afshin
Arjomand, Arash
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-09-07
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Objective.
It has been shown that angiogenesis is a desirable treatment for patients with ischemic heart disease.
We set out to investigate the impact of high-intensity interval training (HIIT) and berberine supplementation on the gene expression of angiogenesis-related factors and caspase-3 protein in rats suffering from myocardial ischemic-reperfusion injury.
Methods.
Fifty rats were divided into the following groups: (1) trained, (2) berberine supplemented, (3) combined, and (4) IR.
Each cohort underwent five sessions of HIIT per week for a duration of 8 weeks followed by induction of ischemia.
Seven days after completion of reperfusion, changes in the gene expression of angiogenesis-related factors and caspase-3 protein were evaluated in the heart tissue.
Results.
We observed a significant difference between four groups in the transcript levels of vascular endothelial cell growth factor (VEGF), fibroblast growth factor-2 (FGF2), and thrombospondin-1(TSP-1) (p≤0.05).
However, the difference in endostatin (ENDO) levels was not significant among the groups despite a discernible reduction (p≥0.05).
Moreover, caspase-3 protein and infarct size were significantly reduced in the intervention groups (p≤0.05), and cardiac function increased in response to these interventions.
Conclusion.
The treatments exert their effect, likely, by reducing caspase-3 protein and increasing the expression of angiogenesis-promoting factors, concomitant with a reduction in inhibitors of the process.
American Psychological Association (APA)
Banaei, Parisa& Nazem, Farzad& Nazari, Afshin& Arjomand, Arash. 2020. Preconditioning Effect of High-Intensity Interval Training (HIIT) and Berberine Supplementation on the Gene Expression of Angiogenesis Regulators and Caspase-3 Protein in the Rats with Myocardial Ischemia-Reperfusion (IR) Injury. BioMed Research International،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1133703
Modern Language Association (MLA)
Banaei, Parisa…[et al.]. Preconditioning Effect of High-Intensity Interval Training (HIIT) and Berberine Supplementation on the Gene Expression of Angiogenesis Regulators and Caspase-3 Protein in the Rats with Myocardial Ischemia-Reperfusion (IR) Injury. BioMed Research International No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1133703
American Medical Association (AMA)
Banaei, Parisa& Nazem, Farzad& Nazari, Afshin& Arjomand, Arash. Preconditioning Effect of High-Intensity Interval Training (HIIT) and Berberine Supplementation on the Gene Expression of Angiogenesis Regulators and Caspase-3 Protein in the Rats with Myocardial Ischemia-Reperfusion (IR) Injury. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1133703
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1133703