The Effects of Music Intervention on Pallidum-DMN Circuit of Schizophrenia
Joint Authors
Luo, Cheng
He, Hui
Yao, Yutong
Duan, Mingjun
Li, Shicai
Li, Cheng
Chen, Xi
Yao, Gang
Chang, Xin
Shu, Haifeng
Wang, Hongming
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-09-21
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Music intervention has been applied to improve symptoms of schizophrenic subjects as a complementary treatment in medicine.
Although the psychiatric symptoms, especially for motivation and emotion, could be increased in schizophrenia, the underlying neural mechanisms remain poorly understood.
We employed a longitudinal study to measure the alteration of striatum functional networks in schizophrenic subjects undergoing Mozart music listening using resting-state functional magnetic resonance imaging (fMRI).
Forty-five schizophrenic inpatients were recruited and randomly assigned to two groups.
Under the standard care with antipsychotic medication, one group received music intervention for 1 month and the other group is set as control.
Both schizophrenic groups were compared to healthy subjects.
Resting-state fMRI was acquired from schizophrenic subjects at baseline and after one-month music intervention and from healthy subjects at baseline.
Striatum network was assessed through seed-based static and dynamic functional connectivity (FC) analyses.
After music intervention, increased static FC was observed between pallidum and ventral hippocampus in schizophrenic subjects.
Increased dynamic FCs were also found between pallidus and subregions of default mode network (DMN), including cerebellum crus and posterior cingulate cortex.
Moreover, static pallidus-hippocampus FC increment was positively correlated with the improvement of negative symptoms in schizophrenic subjects.
Together, these findings provided evidence that music intervention might have an effect on the FC of the striatum-DMN circuit and might be related to the remission of symptoms of schizophrenia.
American Psychological Association (APA)
Yao, Yutong& He, Hui& Duan, Mingjun& Li, Shicai& Li, Cheng& Chen, Xi…[et al.]. 2020. The Effects of Music Intervention on Pallidum-DMN Circuit of Schizophrenia. BioMed Research International،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1133705
Modern Language Association (MLA)
Yao, Yutong…[et al.]. The Effects of Music Intervention on Pallidum-DMN Circuit of Schizophrenia. BioMed Research International No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1133705
American Medical Association (AMA)
Yao, Yutong& He, Hui& Duan, Mingjun& Li, Shicai& Li, Cheng& Chen, Xi…[et al.]. The Effects of Music Intervention on Pallidum-DMN Circuit of Schizophrenia. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1133705
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1133705