Inhibition of Fibrinolysis by Coagulation Factor XIII
Joint Authors
Rijken, Dingeman C.
Uitte de Willige, Shirley
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-06
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The inhibitory effect of coagulation factor XIII (FXIII) on fibrinolysis has been studied for at least 50 years.
Our insight into the underlying mechanisms has improved considerably, aided in particular by the discovery that activated FXIII cross-links α2-antiplasmin (α2AP) to fibrin.
In this review, the most important effects of different cross-linking reactions on fibrinolysis are summarized.
A distinction is made between fibrin-fibrin cross-links studied in purified systems and fibrin-α2AP cross-links studied in plasma or whole blood systems.
While the formation of γ chain dimers in fibrin does not affect clot lysis, the formation of α chain polymers has a weak inhibitory effect.
Only strong cross-linking of fibrin, associated with high molecular weight α chain polymers and/or γ chain multimers, results in a moderate inhibition fibrinolysis.
The formation of fibrin-α2AP cross-links has only a weak effect on clot lysis, but this effect becomes strong when clot retraction occurs.
Under these conditions, FXIII prevents α2AP being expelled from the clot and makes the clot relatively resistant to degradation by plasmin.
American Psychological Association (APA)
Rijken, Dingeman C.& Uitte de Willige, Shirley. 2017. Inhibition of Fibrinolysis by Coagulation Factor XIII. BioMed Research International،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1133721
Modern Language Association (MLA)
Rijken, Dingeman C.& Uitte de Willige, Shirley. Inhibition of Fibrinolysis by Coagulation Factor XIII. BioMed Research International No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1133721
American Medical Association (AMA)
Rijken, Dingeman C.& Uitte de Willige, Shirley. Inhibition of Fibrinolysis by Coagulation Factor XIII. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1133721
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1133721