The Expression of Snail, Galectin-3, and IGF1R in the Differential Diagnosis of Benign and Malignant Pheochromocytoma and Paraganglioma
Joint Authors
Tian, Hao-Ming
Fan, Xiaoli
Deng, Liling
Chen, Tao
Xu, Huan
Li, Yuanmei
Deng, Mingyan
Ren, Yan
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-02-29
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Objective.
The aim of this study was to investigate the expression of Snail, galectin-3, and IGF1R in benign and malignant pheochromocytoma and paraganglioma (PPGL) and explore their role in the diagnosis of malignant PPGL.
Methods.
We retrospectively collected and analyzed surgical tumor tissue from 226 patients initially diagnosed with PPGL who underwent surgery from Jan.
2009 to Jan.
2016 at West China Hospital, Sichuan University.
We observed and quantified the expression of Snail, galectin-3, and IGF1R in paraffin-embedded samples by immunohistochemical staining.
Results.
The significant difference in survival time among the three groups (benign PHEO, benign PGL, and potentially malignant PPGL) was compared by Kaplan-Meier survival analysis.
The positive staining of Snail, galectin-3, and IGF1R in the benign PHEO group was significantly lower than that in the other three groups (P<0.001).
The Kaplan-Meier survival plots indicated that the survival time of the patients with intense positive staining was significantly lower than that of the patients with weak positive staining.
Conclusion.
The intense expression of Snail, galectin-3, and IGF1R may be valuable indicators for the diagnosis of malignant PPGL.
American Psychological Association (APA)
Deng, Liling& Chen, Tao& Xu, Huan& Li, Yuanmei& Deng, Mingyan& Fan, Xiaoli…[et al.]. 2020. The Expression of Snail, Galectin-3, and IGF1R in the Differential Diagnosis of Benign and Malignant Pheochromocytoma and Paraganglioma. BioMed Research International،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1133735
Modern Language Association (MLA)
Deng, Liling…[et al.]. The Expression of Snail, Galectin-3, and IGF1R in the Differential Diagnosis of Benign and Malignant Pheochromocytoma and Paraganglioma. BioMed Research International No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1133735
American Medical Association (AMA)
Deng, Liling& Chen, Tao& Xu, Huan& Li, Yuanmei& Deng, Mingyan& Fan, Xiaoli…[et al.]. The Expression of Snail, Galectin-3, and IGF1R in the Differential Diagnosis of Benign and Malignant Pheochromocytoma and Paraganglioma. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1133735
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1133735