Long Noncoding RNA MALAT1 Promotes Colorectal Cancer Progression by Acting as a ceRNA of miR-508-5p to Regulate RAB14 Expression
Joint Authors
Zhang, Chen
Yao, Kunhou
Zhang, Junjie
Wang, Chenyu
Wang, Chaoyang
Qin, Changjiang
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-12-04
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Accumulating evidence suggested that lncRNA MALAT1 plays critical roles in the commencement and progression of malignant cancers.
Nevertheless, the function of MALAT1 in colorectal cancer (CRC) remains largely unknown.
In the present study, we reported that MALAT1 expression is significantly upregulated in CRC and correlated with advanced TNM stage, lymph node metastasis, and worse prognosis in patients.
Functional assays revealed that MALAT1 knockdown reduced CRC cell growth and invasion abilities in vitro.
Mechanistically, we discovered that MALAT1 may serve as a competing endogenous RNA (ceRNA) to miR-508-5p in CRC progression.
Bioinformatics analysis and luciferase assays confirmed that RAB14 acts as a target of miR-508-5p.
In addition, downregulation of RAB14 reduced the progression of CRC.
Collectively, our findings indicated that MALAT1 could promote CRC progress by sponging miR-508-5p and enhancing RAB14 expression, which provides a therapeutic target in CRC treatment.
American Psychological Association (APA)
Zhang, Chen& Yao, Kunhou& Zhang, Junjie& Wang, Chenyu& Wang, Chaoyang& Qin, Changjiang. 2020. Long Noncoding RNA MALAT1 Promotes Colorectal Cancer Progression by Acting as a ceRNA of miR-508-5p to Regulate RAB14 Expression. BioMed Research International،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1133742
Modern Language Association (MLA)
Zhang, Chen…[et al.]. Long Noncoding RNA MALAT1 Promotes Colorectal Cancer Progression by Acting as a ceRNA of miR-508-5p to Regulate RAB14 Expression. BioMed Research International No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1133742
American Medical Association (AMA)
Zhang, Chen& Yao, Kunhou& Zhang, Junjie& Wang, Chenyu& Wang, Chaoyang& Qin, Changjiang. Long Noncoding RNA MALAT1 Promotes Colorectal Cancer Progression by Acting as a ceRNA of miR-508-5p to Regulate RAB14 Expression. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1133742
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1133742