Mesenchymal Stem Cells Activate the MEKERK Signaling Pathway and Enhance DNA Methylation via DNMT1 in PBMC from Systemic Lupus Erythematosus
Joint Authors
Guo, Zhixuan
Tang, Zengqi
Ai, Xuechen
Qi, Qing
Liu, Xiuting
Huang, Danqi
Li, Zhaofeng
Ji, Suyun
Guo, Qing
Xiong, Hui
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-17
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The defective MEK/ERK signaling pathway and downstream hypomethylation pattern of lymphocytes are crucial for the pathogenesis of systemic lupus erythematosus (SLE).
However, the role that the mesenchymal stem cells play in the MEK/ERK signaling pathway and DNA methylation of peripheral blood mononuclear cells (PBMC) from SLE patients remains unknown.
In this study, we found that the MEK/ERK signaling pathway of PBMC from SLE patients was activated after the coculture with bone marrow-derived mesenchymal stem cells (BM-MSC) compared with that from the control group.
In addition, the expression level of DNA methyltransferase 1 (DNMT1) increased while the levels of CD70, integrin, alpha L (ITGAL), selectin-l, and IL-13 were reduced in PBMC from SLE patients.
However, no obvious effect of BM-MSC on PBMC from healthy controls was observed.
These findings revealed that BM-MSC might downregulate the expression of methylation-sensitive genes and then suppress the autoactivated PBMC via the MEK/ERK signaling pathway.
And it may be one of the mechanisms that BM-MSC ameliorated SLE.
American Psychological Association (APA)
Xiong, Hui& Guo, Zhixuan& Tang, Zengqi& Ai, Xuechen& Qi, Qing& Liu, Xiuting…[et al.]. 2020. Mesenchymal Stem Cells Activate the MEKERK Signaling Pathway and Enhance DNA Methylation via DNMT1 in PBMC from Systemic Lupus Erythematosus. BioMed Research International،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1133756
Modern Language Association (MLA)
Xiong, Hui…[et al.]. Mesenchymal Stem Cells Activate the MEKERK Signaling Pathway and Enhance DNA Methylation via DNMT1 in PBMC from Systemic Lupus Erythematosus. BioMed Research International No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1133756
American Medical Association (AMA)
Xiong, Hui& Guo, Zhixuan& Tang, Zengqi& Ai, Xuechen& Qi, Qing& Liu, Xiuting…[et al.]. Mesenchymal Stem Cells Activate the MEKERK Signaling Pathway and Enhance DNA Methylation via DNMT1 in PBMC from Systemic Lupus Erythematosus. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1133756
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1133756