The Association of Chemokine Gene Polymorphisms with VKH and Behcet’s Disease in a Chinese Han Population
Joint Authors
Kijlstra, Aize
Yang, Peizeng
Yu, Hongsong
Huang, Yang
Cao, Qingfeng
Deng, Jing
Huang, Xinyue
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-14
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
To investigate the association of chemokine gene polymorphisms and Behcet’s disease (BD) and Vogt Koyanagi Harada (VKH) disease in a Chinese Han population.
A case-control study was performed.
Three hundred and seventy-one BD patients, 371 VKH disease patients, and 605 healthy controls were recruited to determine genetic variants of 26 SNPs in 12 chemokine genes with iPLEX Gold genotyping assay and Sequenom MassARRAY or TaqMan SNP assays.
In this study, Puncorr values showed a weak association of five SNPs of five genes in BD and three SNPs of three genes in VKH disease.
However, after Bonferroni correction, the 26 investigated SNPs showed no significant differences in genetic variants, including genotype and allele frequencies, between BD or VKH disease patients and healthy individuals.
Haplotype analysis for the chemokine genes showed a significant association with the TC haplotype of CXCL12 in VKH.
Stratified gender analysis and genotype-phenotype analysis were conducted to analyze the association of the 26 SNPs of 12 chemokine genes with BD and VKH disease.
However, no significant association was observed after Bonferroni correction.
This study showed no association of 26 SNPs in 12 chemokine genes with both BD and VKH disease in a Chinese Han population.
American Psychological Association (APA)
Huang, Yang& Yu, Hongsong& Cao, Qingfeng& Deng, Jing& Huang, Xinyue& Kijlstra, Aize…[et al.]. 2017. The Association of Chemokine Gene Polymorphisms with VKH and Behcet’s Disease in a Chinese Han Population. BioMed Research International،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1133784
Modern Language Association (MLA)
Huang, Yang…[et al.]. The Association of Chemokine Gene Polymorphisms with VKH and Behcet’s Disease in a Chinese Han Population. BioMed Research International No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1133784
American Medical Association (AMA)
Huang, Yang& Yu, Hongsong& Cao, Qingfeng& Deng, Jing& Huang, Xinyue& Kijlstra, Aize…[et al.]. The Association of Chemokine Gene Polymorphisms with VKH and Behcet’s Disease in a Chinese Han Population. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1133784
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1133784