MicroRNA as a Therapeutic Target in Cardiac Remodeling
Joint Authors
Chen, Chao
Ponnusamy, Murugavel
Liu, Cuiyun
Gao, Jinning
Wang, Kun
Li, Peifeng
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-25, 25 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-09-28
Country of Publication
Egypt
No. of Pages
25
Main Subjects
Abstract EN
MicroRNAs (miRNAs) are small RNA molecules that contain 18–25 nucleotides.
The alterations in their expression level play crucial role in the development of many disorders including heart diseases.
Myocardial remodeling is the final pathological consequence of a variety of myocardial diseases.
miRNAs have central role in regulating pathogenesis of myocardial remodeling by modulating cardiac hypertrophy, cardiomyocytes injury, cardiac fibrosis, angiogenesis, and inflammatory response through multiple mechanisms.
The balancing and tight regulation of different miRNAs is a key to drive the cellular events towards functional recovery and any fall in this leads to detrimental effect on cardiac function following various insults.
In this review, we discuss the impact of alterations of miRNAs expression on cardiac hypertrophy, cardiomyocytes injury, cardiac fibrosis, angiogenesis, and inflammatory response.
We have also described the targets (receptors, signaling molecules, transcription factors, etc.) of miRNAs on which they act to promote or attenuate cardiac remodeling processes in different type cells of cardiac tissues.
American Psychological Association (APA)
Chen, Chao& Ponnusamy, Murugavel& Liu, Cuiyun& Gao, Jinning& Wang, Kun& Li, Peifeng. 2017. MicroRNA as a Therapeutic Target in Cardiac Remodeling. BioMed Research International،Vol. 2017, no. 2017, pp.1-25.
https://search.emarefa.net/detail/BIM-1133786
Modern Language Association (MLA)
Chen, Chao…[et al.]. MicroRNA as a Therapeutic Target in Cardiac Remodeling. BioMed Research International No. 2017 (2017), pp.1-25.
https://search.emarefa.net/detail/BIM-1133786
American Medical Association (AMA)
Chen, Chao& Ponnusamy, Murugavel& Liu, Cuiyun& Gao, Jinning& Wang, Kun& Li, Peifeng. MicroRNA as a Therapeutic Target in Cardiac Remodeling. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-25.
https://search.emarefa.net/detail/BIM-1133786
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1133786