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Drug Target Protein-Protein Interaction Networks: A Systematic Perspective
Joint Authors
Feng, Yanghe
Wang, Qi
Wang, Tengjiao
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-06-11
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
The identification and validation of drug targets are crucial in biomedical research and many studies have been conducted on analyzing drug target features for getting a better understanding on principles of their mechanisms.
But most of them are based on either strong biological hypotheses or the chemical and physical properties of those targets separately.
In this paper, we investigated three main ways to understand the functional biomolecules based on the topological features of drug targets.
There are no significant differences between targets and common proteins in the protein-protein interactions network, indicating the drug targets are neither hub proteins which are dominant nor the bridge proteins.
According to some special topological structures of the drug targets, there are significant differences between known targets and other proteins.
Furthermore, the drug targets mainly belong to three typical communities based on their modularity.
These topological features are helpful to understand how the drug targets work in the PPI network.
Particularly, it is an alternative way to predict potential targets or extract nontargets to test a new drug target efficiently and economically.
By this way, a drug target’s homologue set containing 102 potential target proteins is predicted in the paper.
American Psychological Association (APA)
Feng, Yanghe& Wang, Qi& Wang, Tengjiao. 2017. Drug Target Protein-Protein Interaction Networks: A Systematic Perspective. BioMed Research International،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1133810
Modern Language Association (MLA)
Feng, Yanghe…[et al.]. Drug Target Protein-Protein Interaction Networks: A Systematic Perspective. BioMed Research International No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1133810
American Medical Association (AMA)
Feng, Yanghe& Wang, Qi& Wang, Tengjiao. Drug Target Protein-Protein Interaction Networks: A Systematic Perspective. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1133810
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1133810