Animal Models of Tuberculosis Vaccine Research: An Important Component in the Fight against Tuberculosis
Joint Authors
Gong, Wenping
Liang, Yan
Wu, Xueqiong
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-21, 21 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-01-08
Country of Publication
Egypt
No. of Pages
21
Main Subjects
Abstract EN
Tuberculosis (TB), an infectious disease caused by Mycobacterium tuberculosis, is one of the top ten infectious diseases worldwide, and is the leading cause of morbidity from a single infectious agent.
M.
tuberculosis can cause infection in several species of animals in addition to humans as the natural hosts.
Although animal models of TB disease cannot completely simulate the occurrence and development of human TB, they play an important role in studying the pathogenesis, immune responses, and pathological changes as well as for vaccine research.
This review summarizes the commonly employed animal models, including mouse, guinea pig, rabbit, rat, goat, cattle, and nonhuman primates, and their characteristics as used in TB vaccine research, and provides a basis for selecting appropriate animal models according to specific research needs.
Furthermore, some of the newest animal models used for TB vaccine research (such as humanized animal models, zebrafish, Drosophila, and amoeba) are introduced, and their characteristics and research progress are discussed.
American Psychological Association (APA)
Gong, Wenping& Liang, Yan& Wu, Xueqiong. 2020. Animal Models of Tuberculosis Vaccine Research: An Important Component in the Fight against Tuberculosis. BioMed Research International،Vol. 2020, no. 2020, pp.1-21.
https://search.emarefa.net/detail/BIM-1133829
Modern Language Association (MLA)
Gong, Wenping…[et al.]. Animal Models of Tuberculosis Vaccine Research: An Important Component in the Fight against Tuberculosis. BioMed Research International No. 2020 (2020), pp.1-21.
https://search.emarefa.net/detail/BIM-1133829
American Medical Association (AMA)
Gong, Wenping& Liang, Yan& Wu, Xueqiong. Animal Models of Tuberculosis Vaccine Research: An Important Component in the Fight against Tuberculosis. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-21.
https://search.emarefa.net/detail/BIM-1133829
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1133829