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Ticagrelor-Induced Prolongation of the QTc Interval
Joint Authors
Ray, Avik
Najmi, Ahmad
Khandelwal, Gaurav
Sadasivam, Balakrishnan
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-11-07
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Background.
Ticagrelor has been accepted as a class I antiplatelet agent in patients undergoing percutaneous coronary angioplasty (PTCA).
There have been cases reported on ticagrelor being associated with various cardiac conduction defects.
But there is no evidence of QTc prolongation associated with the drug as of yet.
Case Presentation.
A 64-year-old male who underwent PTCA was given ticagrelor.
A baseline electrocardiogram (ECG) showed a QTc of 402 ms.
He returned after 1.5 months with complaints of shortness of breath.
An ECG revealed a prolonged QTc of 468 ms.
Ticagrelor was discontinued in view of ticagrelor-induced dyspnea and the patient was started on clopidogrel.
The other medications were kept unchanged.
The patient returned after a month without any complaints.
A follow-up ECG showed a reduced QTc of 425 ms.
Conclusion.
We present a case of ticagrelor-induced QTc prolongation.
To our knowledge, this is the first case to be reported on the same.
The Naranjo algorithm for causality assessment gave a total score of 6 indicating that the adverse drug reaction falls under the probable category.
American Psychological Association (APA)
Ray, Avik& Najmi, Ahmad& Khandelwal, Gaurav& Sadasivam, Balakrishnan. 2019. Ticagrelor-Induced Prolongation of the QTc Interval. Case Reports in Cardiology،Vol. 2019, no. 2019, pp.1-4.
https://search.emarefa.net/detail/BIM-1133839
Modern Language Association (MLA)
Ray, Avik…[et al.]. Ticagrelor-Induced Prolongation of the QTc Interval. Case Reports in Cardiology No. 2019 (2019), pp.1-4.
https://search.emarefa.net/detail/BIM-1133839
American Medical Association (AMA)
Ray, Avik& Najmi, Ahmad& Khandelwal, Gaurav& Sadasivam, Balakrishnan. Ticagrelor-Induced Prolongation of the QTc Interval. Case Reports in Cardiology. 2019. Vol. 2019, no. 2019, pp.1-4.
https://search.emarefa.net/detail/BIM-1133839
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1133839