Decrease in Anti-HBs Antibodies over Time in Medical Students and Healthcare Workers after Hepatitis B Vaccination
Joint Authors
Sahana, H. V.
Sarala, N.
Prasad, S. R.
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-09-26
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
Hepatitis B is one of the most important occupational hazards among healthcare workers (HCWs).
This study aimed to measure the anti-HBs titres among the medical students and HCWs vaccinated against hepatitis B virus and to determine the association between anti-HBs levels and time since vaccination.
Materials and Methods.
In this cross-sectional study, medical students and healthcare workers who had received all three doses of hepatitis B vaccination and completed at least six months after vaccination since the last dose were included.
3 ml blood was collected from subjects (n=340) and anti-HBs titre was estimated using ELISA.
Results.
A total of 340/400 subjects were aged between 18 and 60 years; 204 were females and 136 males.
The median and interquartile range for time since vaccination were 5 and 5 years, respectively.
Duration since vaccination was ≤5 years in 223 (65.5%), 6–10 years in 84 (24.7%), and >10 years in 33 (9.70%); among them, antibody titres were >10 mIU/ml in 94.1%, 79.7%, and 72.7% subjects, respectively.
There was significant decline in antibody titres as duration of postvaccination increased.
Conclusion.
The proportion of subjects who were unprotected after 5 and 10 years after vaccination were 20% and 27%, respectively.
The need for a booster dose can be made mandatory at least for healthcare professionals.
American Psychological Association (APA)
Sahana, H. V.& Sarala, N.& Prasad, S. R.. 2017. Decrease in Anti-HBs Antibodies over Time in Medical Students and Healthcare Workers after Hepatitis B Vaccination. BioMed Research International،Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1133847
Modern Language Association (MLA)
Sahana, H. V.…[et al.]. Decrease in Anti-HBs Antibodies over Time in Medical Students and Healthcare Workers after Hepatitis B Vaccination. BioMed Research International No. 2017 (2017), pp.1-5.
https://search.emarefa.net/detail/BIM-1133847
American Medical Association (AMA)
Sahana, H. V.& Sarala, N.& Prasad, S. R.. Decrease in Anti-HBs Antibodies over Time in Medical Students and Healthcare Workers after Hepatitis B Vaccination. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1133847
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1133847