Postmenopausal Iron Overload Exacerbated Bone Loss by Promoting the Degradation of Type I Collagen
Joint Authors
Ma, Haile
Xu, Ximing
Jiang, Jun
Cheng, Qian
Zhang, Xiaofei
Zhao, Guoyang
Wang, Yin
Xu, Youjia
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-23
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
117 postmenopausal women were divided into Normal, Bone loss (BL), and Osteoporosis group.
Compared with Normal group (120.96 ± 43.18 μg/L), the serum ferritin (Fer) in BL (223.37 ± 130.27 μg/L) and Osteoporosis group (307.50 ± 161.48 μg/L) was significantly increased (p < 0.05).
Fer level was negatively correlated with BMD (p < 0.01).
TRACP levels in Osteoporosis group (4.37 ± 1.69 U/L) were significantly higher than Normal group (4.10 ± 1.60 U/L, p < 0.05).
ALP levels in Osteoporosis group (112.06 ± 62.05 U/L) were significantly upregulated compared with Normal group (80.22 ± 14.94 U/L, p < 0.05).
β-CTX and PINP were the degradation products of type I collagen.
β-CTX levels in Osteoporosis group (667.90 ± 316.55 ng/L) were significantly increased compared with Normal group (406.06 ± 112.12 ng/L, p < 0.05).
PINP levels in Osteoporosis group (78.03 ± 37.31 μg/L) were significantly higher than Normal group (37.60 ± 13.17 μg/L, p < 0.01).
More importantly, there was a positive correlation between serum Fer and PINP (p < 0.01).
Serum Fer showed a positive correlation of serum β-CTX (p < 0.01).
The overloaded iron improved the degradation of type I collagen.
American Psychological Association (APA)
Cheng, Qian& Zhang, Xiaofei& Jiang, Jun& Zhao, Guoyang& Wang, Yin& Xu, Youjia…[et al.]. 2017. Postmenopausal Iron Overload Exacerbated Bone Loss by Promoting the Degradation of Type I Collagen. BioMed Research International،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1133854
Modern Language Association (MLA)
Cheng, Qian…[et al.]. Postmenopausal Iron Overload Exacerbated Bone Loss by Promoting the Degradation of Type I Collagen. BioMed Research International No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1133854
American Medical Association (AMA)
Cheng, Qian& Zhang, Xiaofei& Jiang, Jun& Zhao, Guoyang& Wang, Yin& Xu, Youjia…[et al.]. Postmenopausal Iron Overload Exacerbated Bone Loss by Promoting the Degradation of Type I Collagen. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1133854
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1133854