Liver Adiposity and Metabolic Profile in Individuals with Chronic Spinal Cord Injury
Joint Authors
Gorgey, Ashraf S.
Rankin, Kathleen C.
O’Brien, Laura C.
Segal, Liron
Khan, M. Rehan
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-30
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Purpose.
To quantify liver adiposity using magnetic resonance imaging (MRI) and to determine its association with metabolic profile in men with spinal cord injury (SCI).
Materials and Methods.
MRI analysis of liver adiposity by fat signal fraction (FSF) and visceral adipose tissue (VAT) was completed on twenty participants.
Intravenous glucose tolerance test was conducted to measure glucose effectiveness (Sg) and insulin sensitivity (Si).
Lipid panel, fasting glucose, glycated hemoglobin (HbA1c), and inflammatory cytokines were also analyzed.
Results.
Average hepatic FSF was 3.7%±2.1.
FSF was positively related to TG, non-HDL-C, fasting glucose, HbA1c, VAT, and tumor necrosis factor alpha (TNF-α).
FSF was negatively related to Si and testosterone.
FSF was positively related to VAT (r=0.48, p=0.032) and TNF-α (r=0.51, p=0.016) independent of age, level of injury (LOI), and time since injury (TSI).
The associations between FSF and metabolic profile were independent of VAT.
Conclusions.
MRI noninvasively estimated hepatic adiposity in men with chronic SCI.
FSF was associated with dysfunction in metabolic profile, central adiposity, and inflammation.
Importantly, liver adiposity influenced metabolic profile independently of VAT.
These findings highlight the significance of quantifying liver adiposity after SCI to attenuate the development of metabolic disorders.
American Psychological Association (APA)
Rankin, Kathleen C.& O’Brien, Laura C.& Segal, Liron& Khan, M. Rehan& Gorgey, Ashraf S.. 2017. Liver Adiposity and Metabolic Profile in Individuals with Chronic Spinal Cord Injury. BioMed Research International،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1133861
Modern Language Association (MLA)
Rankin, Kathleen C.…[et al.]. Liver Adiposity and Metabolic Profile in Individuals with Chronic Spinal Cord Injury. BioMed Research International No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1133861
American Medical Association (AMA)
Rankin, Kathleen C.& O’Brien, Laura C.& Segal, Liron& Khan, M. Rehan& Gorgey, Ashraf S.. Liver Adiposity and Metabolic Profile in Individuals with Chronic Spinal Cord Injury. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1133861
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1133861