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An Imaging and Histological Study on Intrahepatic Microvascular Passage of Contrast Materials in Rat Liver
Joint Authors
Ni, Y.
Liu, Jianjun
Xia, Qian
Feng, Yuanbo
Yin, Ting
Liu, Yewei
Zhang, Guozhi
Tong, Linjun
Willemyns, Robin
Yu, Jie
Huang, Gang
Oyen, Raymond
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-15
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Background.
Lipiodol has been applied for decades in transarterial chemoembolization to treat liver malignancies, but its intrahepatic pathway through arterioportal shunt (APS) in the liver has not been histologically revealed.
This rodent experiment was conducted to provide evidence for the pathway of Lipiodol delivered through the hepatic artery (HA) but found in the portal vein (PV) and to elucidate the observed unidirectional APS.
Methods.
Thirty rats were divided into 5 groups receiving systemic or local arterial infusion of red-stained iodized oil (RIO) or its hydrosoluble substitute barium sulfate suspension (BSS), or infusion of BSS via the PV, monitored by real-time digital radiography.
Histomorphology of serial frozen and paraffin sections was performed and quantified.
Results.
After HA infusion, RIO and BSS appeared extensively in PV lumens with peribiliary vascular plexus (PVP) identified as the responsible anastomotic channel.
After PV infusion, BSS appeared predominantly in the PV and surrounding sinusoids and to a much lesser extent in the PVP and HA (P<0.001).
Fluid mechanics well explains the one-way-valve phenomenon of APS.
Conclusions.
Intravascularly injected rat livers provide histomorphologic evidences: (1) the PVP exists in between the HA and PV, which is responsible to the APS of Lipiodol; and (2) the intrahepatic vascular inflow appears HA-PVP-PV unidirectional without a physical one-way valve, which can be postulated by the fluid mechanics.
American Psychological Association (APA)
Xia, Qian& Feng, Yuanbo& Yin, Ting& Liu, Yewei& Zhang, Guozhi& Liu, Jianjun…[et al.]. 2017. An Imaging and Histological Study on Intrahepatic Microvascular Passage of Contrast Materials in Rat Liver. BioMed Research International،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1133902
Modern Language Association (MLA)
Xia, Qian…[et al.]. An Imaging and Histological Study on Intrahepatic Microvascular Passage of Contrast Materials in Rat Liver. BioMed Research International No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1133902
American Medical Association (AMA)
Xia, Qian& Feng, Yuanbo& Yin, Ting& Liu, Yewei& Zhang, Guozhi& Liu, Jianjun…[et al.]. An Imaging and Histological Study on Intrahepatic Microvascular Passage of Contrast Materials in Rat Liver. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1133902
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1133902