Hepatoprotective Effect of Oleuropein-Rich Extract from Olive Leaves against Cadmium-Induced Toxicity in Mice
Joint Authors
Sayadi, Sami
Bouallagui, Zouhaier
Fki, Ines
Mahmoudi, Asma
Jemai, Hedya
Feryeni, Anwar
Choura, Sirine
Chamkha, Mohamed
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-04-04
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Cadmium (Cd) is a harmful pollutant which mainly affects the liver and kidney.
In this work, we investigated the hepatoprotective effects of olive leaf extract based on oleuropein against hepatic cadmium toxicity in mice.
Three groups of animals were used: the first one served as the control (C); the second one received intraperitoneal injection of cadmium 2 mg/kg b.w.
(CD), administered five times during two weeks; and the third group received the same doses of Cd and simultaneously 16 mg/kg b.w.
of oleuropein.
Results showed that Cd induced a significant increase in liver injury biomarkers coupled with enhanced lipid peroxidation (MDA) and significant depletion of antioxidants (CAT and SOD).
Histological and immunohistochemical analysis confirmed these findings.
In fact, we observed a severe central lobular apoptosis and inflammation around central veins.
Cotreatment with oleuropein significantly reduced the oxidative damage induced by cadmium.
Our findings suggest that oleuropein could be used in the prevention of Cd hepatotoxicity.
American Psychological Association (APA)
Jemai, Hedya& Mahmoudi, Asma& Feryeni, Anwar& Fki, Ines& Bouallagui, Zouhaier& Choura, Sirine…[et al.]. 2020. Hepatoprotective Effect of Oleuropein-Rich Extract from Olive Leaves against Cadmium-Induced Toxicity in Mice. BioMed Research International،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1133928
Modern Language Association (MLA)
Jemai, Hedya…[et al.]. Hepatoprotective Effect of Oleuropein-Rich Extract from Olive Leaves against Cadmium-Induced Toxicity in Mice. BioMed Research International No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1133928
American Medical Association (AMA)
Jemai, Hedya& Mahmoudi, Asma& Feryeni, Anwar& Fki, Ines& Bouallagui, Zouhaier& Choura, Sirine…[et al.]. Hepatoprotective Effect of Oleuropein-Rich Extract from Olive Leaves against Cadmium-Induced Toxicity in Mice. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1133928
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1133928