Paracetamol in Patent Ductus Arteriosus Treatment: Efficacious and Safe?
Joint Authors
Dessì, Angelica
Bardanzellu, Flaminia
Neroni, Paola
Fanos, Vassilios
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-25, 25 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-30
Country of Publication
Egypt
No. of Pages
25
Main Subjects
Abstract EN
In preterm infants, failure or delay in spontaneous closure of Ductus Arteriosus (DA), resulting in the condition of Patent Ductus Arteriosus (PDA), represents a significant issue.
A prolonged situation of PDA can be associated with several short- and long-term complications.
Despite years of researches and clinical experience on PDA management, unresolved questions about the treatment and heterogeneity of clinical practices in different centers still remain, in particular regarding timing and modality of intervention.
Nowadays, the most reasonable strategy seems to be reserving the treatment only to hemodynamically significant PDA.
The first-line therapy is medical, and ibuprofen, related to several side effects especially in terms of nephrotoxicity, is the drug of choice.
Administration of oral or intravenous paracetamol (acetaminophen) recently gained attention, appearing effective as traditional nonsteroidal anti-inflammatory drugs (NSAIDs) in PDA closure, with lower toxicity.
The results of the studies analyzed in this review mostly support paracetamol efficacy in ductal closure, with inconstant low and transient elevation of liver enzymes as reported side effect.
However, more studies are needed to confirm if this therapy shows a real safety profile and to evaluate its long-term outcomes, before considering paracetamol as first-choice drug in PDA treatment.
American Psychological Association (APA)
Bardanzellu, Flaminia& Neroni, Paola& Dessì, Angelica& Fanos, Vassilios. 2017. Paracetamol in Patent Ductus Arteriosus Treatment: Efficacious and Safe?. BioMed Research International،Vol. 2017, no. 2017, pp.1-25.
https://search.emarefa.net/detail/BIM-1133933
Modern Language Association (MLA)
Bardanzellu, Flaminia…[et al.]. Paracetamol in Patent Ductus Arteriosus Treatment: Efficacious and Safe?. BioMed Research International No. 2017 (2017), pp.1-25.
https://search.emarefa.net/detail/BIM-1133933
American Medical Association (AMA)
Bardanzellu, Flaminia& Neroni, Paola& Dessì, Angelica& Fanos, Vassilios. Paracetamol in Patent Ductus Arteriosus Treatment: Efficacious and Safe?. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-25.
https://search.emarefa.net/detail/BIM-1133933
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1133933