Dynamics of Neutrophils-to-Lymphocyte Ratio Predict Outcomes of PD-1PD-L1 Blockade
Joint Authors
Arkenau, Hendrik-Tobias
Boussios, Stergios
Uccello, Mario
Kasenda, Benjamin
Mak, Gabriel
McClelland, Anissa
Forster, Martin
Moschetta, Michele
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-11-28
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Introduction.
Baseline neutrophil-to-lymphocyte ratio (NLR) has been repeatedly reported as a significant prognostic factor in advanced cancer patients.
We explored whether changes in NLR may predict outcome of advanced cancer patients enrolled into phase 1 trials and treated with PD-1/PD-L1 inhibitors.
Patients and Methods.
Advanced cancer patients enrolled into phase 1 trials between September 2013 and May 2016 and treated with anti-PD-1/PD-L1 agents were included in this retrospective study.
NLR was calculated at baseline and after 2 cycles of treatment.
Royal Marsden Hospital (RMH) prognostic score and Eastern Cooperative Group (ECOG) performance status (PS) were determined at baseline.
Kaplan-Meier estimation and Cox regression analyses were used to assess the impact of NLR dynamics on PFS.
Results.
Among the 55 patients eligible, 26 (47%) were treated with anti-PD-L1 monotherapy, 22 (40%) received single agent anti-PD-1, and 7 (13%) were given a tyrosine kinase inhibitor (TKI) plus a PD-1 inhibitor.
Neither ECOG PS nor RMH prognostic score was significantly associated with PFS in our cohort, whereas changes in NLR significantly impacted on PFS.
Conclusion.
Changes in the NLR may be a useful predicting factor in advanced cancer patients treated with anti-PD-1/PD-L1 agents.
Further prospective trials are needed to verify these findings.
American Psychological Association (APA)
Moschetta, Michele& Uccello, Mario& Kasenda, Benjamin& Mak, Gabriel& McClelland, Anissa& Boussios, Stergios…[et al.]. 2017. Dynamics of Neutrophils-to-Lymphocyte Ratio Predict Outcomes of PD-1PD-L1 Blockade. BioMed Research International،Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1133970
Modern Language Association (MLA)
Moschetta, Michele…[et al.]. Dynamics of Neutrophils-to-Lymphocyte Ratio Predict Outcomes of PD-1PD-L1 Blockade. BioMed Research International No. 2017 (2017), pp.1-5.
https://search.emarefa.net/detail/BIM-1133970
American Medical Association (AMA)
Moschetta, Michele& Uccello, Mario& Kasenda, Benjamin& Mak, Gabriel& McClelland, Anissa& Boussios, Stergios…[et al.]. Dynamics of Neutrophils-to-Lymphocyte Ratio Predict Outcomes of PD-1PD-L1 Blockade. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1133970
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1133970