Effects of Switching from Anti-VEGF Treatment to Triamcinolone Acetonide in Eyes with Refractory Macular Edema Associated with Diabetic Retinopathy or Retinal Vein Occlusion
Joint Authors
Oshitari, Toshiyuki
Takatsuna, Yoko
Tatsumi, Tomoaki
Baba, Takayuki
Yamamoto, Shuichi
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-20
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Purpose.
To evaluate the efficacy of switching from intravitreal antivascular endothelial growth factor (VEGF) agents to triamcinolone acetonide (TA) in eyes with diabetic macular edema (DME) or with retinal vein occlusion-associated macular edema (RVO-ME) on the resolution of the macular edema (ME).
Methods.
The medical records of 11 eyes of 11 patients with DME and 9 eyes of 9 patients with RVO-ME whose MEs were refractory to anti-VEGF treatment were reviewed.
The central retinal thickness (CRT), best-corrected visual acuity (BCVA), intraocular pressure (IOP), and the mean interval of the recurrences were measured during the anti-VEGF treatment and after switching to the TA injections.
Results.
Switching to TA injections significantly increased the mean interval for recurrences from 9.2±2.7 weeks to 22.3±12.9 weeks in eyes with DME (P=0.006).
In eyes with RVO-ME, the mean period of recurrence was 12.3±5.6 weeks before and 11.6±4.4 weeks after the switch (P=0.44).
The mean interval for recurrence was extended to more than 8 weeks in 7 of 11 eyes with DME, but none of the eyes with RVO-ME had a prolongation of more than 4 weeks.
An elevation of the IOP was observed in 3 of the 20 eyes after the TA injection.
Conclusions.
These findings indicate that switching to TA injections can be a good option for DME eyes refractory to anti-VEGF injections but not for the RVO-ME eyes.
American Psychological Association (APA)
Tatsumi, Tomoaki& Oshitari, Toshiyuki& Baba, Takayuki& Takatsuna, Yoko& Yamamoto, Shuichi. 2020. Effects of Switching from Anti-VEGF Treatment to Triamcinolone Acetonide in Eyes with Refractory Macular Edema Associated with Diabetic Retinopathy or Retinal Vein Occlusion. BioMed Research International،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1133974
Modern Language Association (MLA)
Tatsumi, Tomoaki…[et al.]. Effects of Switching from Anti-VEGF Treatment to Triamcinolone Acetonide in Eyes with Refractory Macular Edema Associated with Diabetic Retinopathy or Retinal Vein Occlusion. BioMed Research International No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1133974
American Medical Association (AMA)
Tatsumi, Tomoaki& Oshitari, Toshiyuki& Baba, Takayuki& Takatsuna, Yoko& Yamamoto, Shuichi. Effects of Switching from Anti-VEGF Treatment to Triamcinolone Acetonide in Eyes with Refractory Macular Edema Associated with Diabetic Retinopathy or Retinal Vein Occlusion. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1133974
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1133974