Curcumin Ameliorates Diabetic Nephropathy by Suppressing NLRP3 Inflammasome Signaling
Joint Authors
Lu, Miaomiao
Yin, Nanchang
Liu, Wei
Cui, Xiangfei
Chen, Shuo
Wang, Ermin
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-17
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Diabetic nephropathy (DN) is the leading cause of end-stage renal disease, partly because of the lack of effective treatments for DN.
Curcumin has been shown to exert strong antifibrotic effects in DN, but the underlying mechanisms are not well characterized.
In this study, we sought to determine the effects of curcumin on diabetic renal disease in db/db mice and characterize the underlying mechanism of action.
We administered curcumin to db/db mice for 16 weeks.
In comparison to mock-treated db/db mice, curcumin-treated mice showed diminished renal hypertrophy, reduced mesangial matrix expansion, and a lower level of albuminuria.
Furthermore, the upregulated protein and mRNA expressions of collagen IV and fibronectin in the renal cortices of the db/db mice were inhibited by curcumin treatment.
Additionally, curcumin treatment was associated with significant reductions in mature interleukin-1β, cleaved caspase-1, and NLRP3 protein levels in the renal cortices of db/db mice as well as in HK-2 cells exposed to high glucose concentration.
In summary, curcumin, a potent antifibrotic agent, is a promising treatment for DN, and its renoprotective effects appear to be mediated by the inhibition of NLRP3 inflammasome activity.
American Psychological Association (APA)
Lu, Miaomiao& Yin, Nanchang& Liu, Wei& Cui, Xiangfei& Chen, Shuo& Wang, Ermin. 2017. Curcumin Ameliorates Diabetic Nephropathy by Suppressing NLRP3 Inflammasome Signaling. BioMed Research International،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1133978
Modern Language Association (MLA)
Lu, Miaomiao…[et al.]. Curcumin Ameliorates Diabetic Nephropathy by Suppressing NLRP3 Inflammasome Signaling. BioMed Research International No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1133978
American Medical Association (AMA)
Lu, Miaomiao& Yin, Nanchang& Liu, Wei& Cui, Xiangfei& Chen, Shuo& Wang, Ermin. Curcumin Ameliorates Diabetic Nephropathy by Suppressing NLRP3 Inflammasome Signaling. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1133978
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1133978