CYP1B1 G199T Polymorphism Affects Prognosis of NSCLC Patients with the Potential to Be an Indicator and Target for Precise Drug Intervention
Joint Authors
Li, Fengzhou
Zhao, Shilei
Guo, Tao
Li, Jinxiu
Gu, Chundong
Zhang, Qi
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-09
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
CYP1B1 gene single nucleotide polymorphisms G119T, C432G, and A453G were tested among 164 NSCLC patients treated by Video-Assisted Thoracoscopic Surgery.
After a follow-up period of 5 years, it was found that CYP1B1 G119T mutant genotypes were related to a higher risk of tumor recurrence and death after surgical resection.
However, C432G and A453G genotypes had no influence on long-term prognosis of the study cohort.
Thus, G199T alleles are supposed to be an auxiliary predictor for prognosis of NSCLC patients and a potential target for precise drug intervention, as well as a candidate for further anticancer drug research.
American Psychological Association (APA)
Li, Fengzhou& Guo, Tao& Zhang, Qi& Li, Jinxiu& Zhao, Shilei& Gu, Chundong. 2017. CYP1B1 G199T Polymorphism Affects Prognosis of NSCLC Patients with the Potential to Be an Indicator and Target for Precise Drug Intervention. BioMed Research International،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1133995
Modern Language Association (MLA)
Li, Fengzhou…[et al.]. CYP1B1 G199T Polymorphism Affects Prognosis of NSCLC Patients with the Potential to Be an Indicator and Target for Precise Drug Intervention. BioMed Research International No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1133995
American Medical Association (AMA)
Li, Fengzhou& Guo, Tao& Zhang, Qi& Li, Jinxiu& Zhao, Shilei& Gu, Chundong. CYP1B1 G199T Polymorphism Affects Prognosis of NSCLC Patients with the Potential to Be an Indicator and Target for Precise Drug Intervention. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1133995
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1133995
