Characterization and Identification of Cryptic Biopeptides in Carya illinoinensis (Wangenh K. Koch) Storage Proteins
Joint Authors
Barboza-Corona, Jose Eleazar
León-Galván, Ma. Fabiola
Mares-Mares, Everardo
Gutiérrez-Vargas, Santiago
Pérez-Moreno, Luis
Ordoñez-Acevedo, Leandro G.
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-11-27
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The objective of this research was to identify and characterize the encoded peptides present in nut storage proteins of Carya illinoinensis.
It was found, through in silico prediction, proteomic analysis, and MS spectrometry, that bioactive peptides were mainly found in albumin and glutelin fractions.
Glutelin was the major fraction with ~53% of the nut storage proteins containing at least 21 peptides with different putative biological activities, including antihypertensives, antioxidants, immunomodulators, protease inhibitors, and inhibitors of cell cycle progression in cancer cells.
Data showed that using 50 μg/mL tryptic digests of enriched peptides obtained from nut glutelins is able to induce up to 19% of apoptosis in both HeLa and CasKi cervical cancer cells.
To our knowledge, this is the first report that shows the potential value of the nut-encoded peptides to be considered as adjuvants in cancer therapies.
American Psychological Association (APA)
Mares-Mares, Everardo& Gutiérrez-Vargas, Santiago& Pérez-Moreno, Luis& Ordoñez-Acevedo, Leandro G.& Barboza-Corona, Jose Eleazar& León-Galván, Ma. Fabiola. 2017. Characterization and Identification of Cryptic Biopeptides in Carya illinoinensis (Wangenh K. Koch) Storage Proteins. BioMed Research International،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1134005
Modern Language Association (MLA)
Mares-Mares, Everardo…[et al.]. Characterization and Identification of Cryptic Biopeptides in Carya illinoinensis (Wangenh K. Koch) Storage Proteins. BioMed Research International No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1134005
American Medical Association (AMA)
Mares-Mares, Everardo& Gutiérrez-Vargas, Santiago& Pérez-Moreno, Luis& Ordoñez-Acevedo, Leandro G.& Barboza-Corona, Jose Eleazar& León-Galván, Ma. Fabiola. Characterization and Identification of Cryptic Biopeptides in Carya illinoinensis (Wangenh K. Koch) Storage Proteins. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1134005
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1134005