Controlled release of antifungal miconazole nitrate from crosslinked poly (vinyl alcohol)‎ hydrogel

Abstract EN

Poly (vinyl alcohol) hydrogel was prepared by the reaction between 99% hydrolyzed poly (vinyl alcohol) with gluteraldehyde as a cross linking agent .

The hydrogel was loaded with antifungal Miconazole nitrate.

The swelling ratio of the polymer antifungal delivery system was determined in Simulated Gastric Fluid SGF, Simulated Intestinal Fluid SIF and distilled water.

The release rate of Miconazole nitrate from hydrogel was studied by using U.

V.

technique at constant temperature ( 37 oC ) in SGF and SIF .

The mechanism of degradation for the polymer antifungal delivery was also determined by bulk erosion mechanism .

Finally, the inhibition zone diameters for Miconazole nitrate , polymer miconazole nitrate delivery and polymer alone were studied against three types of fungi , Candida albicans, Cryptococcus neoformans and Fusarium oxysporum.